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SHH Medulloblastoma
•
Majority of nodular/desmoplastic MBs are
included within the SHH subgroup. However
around 50% of SHH subgroup MB have other
histological subtypes, including classical, large
cell/anaplastic, and MBEN varieties.
•
Individuals with germline mutations of the SHH
receptor PTCH have Gorlin’s syndrome