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Group 3 Medulloblastoma
•
Subgroup of MB with the worst prognosis
•
Majority classical histology and include the majority of
large-cell/anaplastic tumours
•
M > F, and arise in infants and older children, but only
rarely in adults
•
Frequently present with metastases.
•
Characterized by high-level amplification of the
MYC
proto-oncogene, and almost all cases exhibit aberrant
MYC
expression
•
Group 3 MB genome exhibits high levels of genomic
instability and often harbours gains of chromosomes 1q,
7, and 17q, and deletions of 10q, 11, 16q, and 17p.