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SHH Medulloblastoma
•
Include
TP53
-mutant and
TP53
-wildtype
subgroups
•
Named after the sonic hedgehog signalling
pathway, considered to drive tumour initiation in
the majority of cases
•
Frequency bimodal, and is frequent in both
infants aged less than 3 years and adults
•
M:F ratio approximately 1:1.
•
Prognosis similar to Group 4 and intermediate
between WNT and Group 3