2016 OMB Summer Meeting

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Protein Detections and Microarrays: 2000 - 2005
 Designed and prepared surfaces for protein immobilization in an array format.
 Improved protein printing process to generate high quality protein microarrays.
 Applied antibody microarrays on atherosclerosis, insulin resistance and liver cancer
biomarker discovery and early diagnosis.
 Evaluated proximity ligation technology for ultra-sensitive protein detection based on
aptamers and antibodies.
June 1998 – July 2000 Senior Scientist and Chemistry Lead, LjL Biosystems, Sunnyvale,
California (acquired by Molecular Devices, Inc. in 2000)
 Designed and synthesized new long lifetime fluorescent labels for energy-transfer and
polarization applications for pharmaceutical entities screening.
 Labelled protein, peptide and small molecules (GTP, cAMP, cGMP etc) with reactive
fluorophores and developed preliminary testing to demonstrate the assay feasibility.
 Supervised external collaborations related to synthetic fluorophore chemistry and two
associates.
Jan 1994 – May 1998 Research Associate, Department of Chemistry, Univ. of Connecticut
 Synthesized benzyl ethers, sulfur-containing cyclic and acyclic compounds, organic
phosphates and their photosensitized deprotection
 Photosensitized debromination of 2’-deoxy-8-bromoguanosine and its application in
oligonucleotide
 Managed lab of 6 graduate students and 3-4 undergraduate students.
July 1992-July 1993 Postdoctoral Research Fellow, Institute of Organic Chemistry,
Universität Bern, Switzerland.
 Multi-step synthesis of bipyridine derivatives as signal transducer and biosensor.
 Synthesis of organometallic compounds and study mechanisms on reductive cleavage
Jan 1989-May 1992 Graduate Research Assistant
Université Libre de Bruxelles, Brussels, Belgium; Graduated with highest honor
 Application of high intensity ultrasound for heterogeneous organic reaction system
 Studies of the influence of experimental parameters on sonochemical organic reactions
 Synthesis of organometallic compound intermediates
Oct 1991-Jan 1992 Exchange Researcher, Department of Chemical Development,
Continental Pharma INC, Searle European Development Center, Belgium.
 The influence of ultrasound on bromination of substituted toluene with NBS
 Synthesis of drug intermediates
Aug 1990-Dec 1990 Exchange Researcher, Université Joseph Fourier, Grenoble, France.
 The influence of ultrasound on lithium-modified Barbier reaction of carboxylic acids
and lithium carboxylates.
Patent Applications:
20 patents (15 with Agilent). Available upon request.
AOAC OMB Meeting Book 274