172
Biophysical Society 58
th
Annual Meeting, San Francisco, California
3254-P
lat
2:15
pm
OVERCOMING REVERSE RATE DEPENDENCE IN VENTRICULAR
CELL MODELS.
Megan A. Cummins
, Pavan Dalal, Marco Bugana,
Stefano Severi, Eric Sobie
3255-P
lat
2:30
pm
ELUCIDATING METABOLIC VARIABILITY IN ISOGENIC
MICROBIAL POPULATIONS ARISING DUE TO NOISE IN
PROTEIN EXPRESSION.
Piyush Labhsetwar
, John Cole,
Nathan Price, Zaida Luthey-Schulten
3256-P
lat
2:45
pm
COMPUTATIONAL MODELING OF GRANULOMA FORMATION
IN TUBERCULOSIS YIELDS INSIGHTS INTO BOTH INFECTION
AND TREATMENT. Nicholas A. Cilfone, Elsje Pienaar,
Denise E. Kirschner,
Jennifer J. Linderman
1:00
pm
–3:00
pm
, R
oom
305
Platform
Cardiac Muscle II
Co-Chairs
Satish Rao, Icahn School of Medicine at Mount Sinai
Steven Wu, South Dakota State University
3257-P
lat
1:00
pm
E-C COUPLING ALTERATIONS AND SPONTANEOUS ACTIVITY
IN MICE CARRYING CARDIAC TROPONIN T MUTATIONS.
Josè Manuel Pioner
, Raffaele Coppini, Cecilia Ferrantini, Benedetta Tosi,
Luca Mazzoni, Rachel Moore, Elisabetta Cerbai, Alessandro Mugelli,
Jil Tardiff, Chiara Tesi, Corrado Poggesi
3258-P
lat
1:15
pm
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY: UNEQUAL
EXPRESSION OF MUTANT AND WILDTYPE MYOSIN IN
INDIVIDUAL MYOCYTES AS TRIGGER FOR FUNCTIONAL
IMPAIRMENT OF THE HEART?
Judith Montag
, Snigdha Tripathi,
Jan Köhler, Dunda E. Sebastian, Benjamin Seebohm, Dejan List,
Matinmehr Faramarz, Andreas Perrot, Özcelik Celim, Antonio Francino,
Fransisco Navarro-Lopéz, William J. McKenna, Jolanda van der Velden,
Bernhard Brenner, Kraft Theresia
3259-P
lat
1:30
pm
MULTI-SCALE BIOMECHANICS IN A MARFAN SYNDROME
MODEL OF DILATED CARDIOMYOPATHY.
Satish Rao
,
Emily Chiu, Jason R. Cook, Jia-Jye Lee, Ludovic Bénard, Roger J. Hajjar,
Francesco Ramirez, Kevin D. Costa
3260-P
lat
1:45
pm
EFFECTS OF NITROSYLATION ON CARDIAC MYOFILAMENT
PROTEINS.
Steven C. Wu
, Maria E. Moutsoglou, John M. Robinson
3261-P
lat
2:00
pm
SARCOMERE LENGTH-VENTRICULAR FILLING PRESSURE
RELATIONSHIP INTHE PERFUSEDMURINE HEART VISUALIZED
WITH 2-PHOTON FLUORESCENCE MICROSCOPY.
Michael E. Nance, Charmain A. Fernando, Anne K. Gibson,
Laurin M. Hanft, Steven S. Segal, Kerry S. McDonald,
Timothy L. Domeier
3262-P
lat
2:15
pm
REAL-TIME IMAGING OF SARCOMERE DYNAMICS IN THE
MOUSE HEART IN VIVO.
Fuyu Kobirumaki-Shimozawa
,
Kotaro Oyama, Akari Mizuno, Takako Terui, Togo Shimozawa,
Takashi Ohki, Shin’ichi Ishiwata, Norio Fukuda
3263-P
lat
2:30
pm
END SYSTOLIC STRAIN RATE, NOT AFTERLOAD, CONTROLS
MYOCARDIAL RELAXATION.
Charles S. Chung
, Kenneth S. Campbell
3264-P
lat
2:45
pm
EXPERIMENTALLY INCREASING TITIN COMPLIANCE IN A
NOVEL MOUSE MODEL ATTENUATES THE FRANK-STARLING
MECHANISM BUT HAS A BENEFICIAL EFFECT ON DIASTOLE.
Mei Methawasin
, Kirk R. Hutchinson, Eun-Jeong Lee, John E. Smith III,
Chandra Saripalli, Carlos G. Hidalgo, Henk L. Granzier
1:00
pm
–3:00
pm
, R
oom
306
Platform
Structure, Dynamics, and Allostery in Drug
Target Interactions
Co-Chairs
Iris Antes, Technical University of Munich, Germany
Roman Agafonov, Brandeis University
3265-P
lat
1:00
pm
FLEXIBLE CDOCKER: DEVELOPMENT AND APPLICATION
OF A PSEUDO-EXPLICIT STRUCTURE-BASED DOCKING
METHOD WITHIN CHARMM.
Jessica K. Gagnon
, Sean M. Law,
Charles L. Brooks III
3266-P
lat
1:15
pm
HOWENZYMES ACCESS CAGED SUBSTRATES? UNDERSTANDING
TARGETED HYDROLYSIS OF CYCLIC AMP BY
PHOSPHODIESTERASE-PROTEIN KINASE A INTERACTIONS.
Nikhil K. Tulsian
, Srinath Krishnamurthy, Ganesh S. Anand
3267-P
lat
1:30
pm
CRYSTALLOGRAPHIC STRUCTURE OF A SMALL MOLECULE
SIRT1 ACTIVATOR/ENZYME COMPLEX.
Han Dai
, Huizhen Zhao,
Yong Jiang, Sharon M. Sweitzer, Beth Pietrak, Benjamin Schwartz,
William Miller, Erding Hu, James L. Ellis
3268-P
lat
1:45
pm
A CONSERVED WATER-MEDIATED HYDROGEN BOND
NETWORK UNDERLIES SELECTIVITY OF THE KINASE
INHIBITOR BOSUTINIB.
Nicholas M. Levinson
, Steven G. Boxer
3269-P
lat
2:00
pm
MOLECULAR MECHANISMS UNDERLYING THE CLINICAL
SUCCESS OF THE CANCER DRUG GLEEVEC.
Roman V. Agafonov
, Chris Wilson, Renee Otten, Vanessa Buosi,
Dorothee Kern
3270-P
lat
2:15
pm
FINDING HIDDEN ALLOSTERIC SITES IN PROTEINS.
Gregory R. Bowman
, Phillip L. Geissler, Susan Marqusee
3271-P
lat
2:30
pm
COMPUTATIONAL PREDICTION OF PROTEIN-PEPTIDE
BINDING.
Iris Antes
, Manuel Glaser, Atanas Patronov
3272-P
lat
2:45
pm
education
travel
awardee
RASTERING THE INFLUENZA VIRUS SURFACE WITH
MOLECULAR RULERS AND NANOPARTICLES TO DESIGN
OPTIMAL MULTIVALENT INHIBITORS.
Daniel Lauster
,
Victor Bandlow, Henry Memzcak, Sumati Bhatia, Christian Sieben,
Walter Stöcklein, Oliver Seitz, Rainer Haag, Andreas Herrmann
