40
Biophysical Society 58
th
Annual Meeting, San Francisco, California
566-P
os
B
oard
#B321
MOLECULAR MODELING AND STRUCTURAL DOCKING OF
A RYANODINE RECEPTOR SPRY2 DOMAIN. Li Zhu, Ruiwu Wang,
S. R. Wayne Chen, Terence Wagenknecht,
Zheng Liu
567-P
os
B
oard
#B322
A REGULATORY COMPONENT OF THE HUMAN RYANODINE
RECEPTOR 2 N-TERMINUS. Lubomir Borko,
Vladena Bauerova-Hlinkova,
Alexandra Zahradnikova
, Julius Kostan,
Konrad Beck, Juraj Gasperik, Eva Hostinova, F. Anthony Lai, Jozef Sevcik
568-P
os
B
oard
#B323
DIVERGENT EFFECTS OF DISEASE-ASSOCIATED MUTATIONS
ON TYPE 2 RYANODINE RECEPTOR CHANNEL.
Nagomi Kurebayashi
, Takashi Murayama, Akira Uehara,
Midori Yasukochi, Takashi Sakurai
569-P
os
B
oard
#B324
CRYSTAL STRUCTURE OF CARDIAC RYANODINE RECEPTOR
N-TERMINAL REGION CONTAINS UNIQUE ANION BINDING
SITE TARGETED BY DISEASE-ASSOCIATED MUTATIONS.
Lynn Kimlicka
, Ching-Chieh Tung, Anna-Carin C. Carlsson,
Paolo A. Lobo, Zhiguang Yuchi, Filip Van Petegem
570-P
os
B
oard
#B325
ARRHYTHMOGENIC MECHANISMS IN CATECHOLAMINER-
GIC POLYMORPHIC VENTRICULAR TACHYCARDIA LINKED
TO RYR2 LOSS-OF-FUNCTION MUTATION.
Yan-Ting Zhao
,
Carmen R. Valdivia, Georgina B. Gurrola, Cong Li, Patricia P. Powers,
Héctor H. Valdivia
571-P
os
B
oard
#B326
PREVENTING RYR2-S2808
AND RYR2-S2814 PHOSPHORYLATION DOES NOT ALTER
THE
β
-ADRENERGIC RESPONSE OF MOUSE HEARTS.
Emmanuel Camors
, Randall Loaiza, Francisco Alvarado, Yanting Zhao,
Patricia Powers, Hector H. Valdivia
572-P
os
B
oard
#B327
SUPPRESSED RYR2 FUNCTION REPRESENTS A COMMON
CAUSE OF IDIOPATHIC VENTRICULAR FIBRILLATION AND
SUDDEN CARDIAC DEATH.
Xiaowei Zhong
, Yijun Tang,
Ruiwu Wang, Vern Hsen Tan, Yingjie Liu, Lin Zhang, Carlo Napolitano,
Silvia Priori, SuiRong Wayne Chen
573-P
os
B
oard
#B328
SUPPRESSION OF SPONTANEOUS CA
2+
RELEASE BY
CARDIOPROTECTIVE DRUGS.
Jingqun Zhang
, Chris D. Smith,
Qiang Zhou, Jianmin Xiao, Guogen Wu, Alma Nani, Thomas G. Back,
Michael Fill, S.R. Wayne Chen
574-P
os
B
oard
#B329
CRYO-EM STUDIES OF RYR1 CHANNEL IN DETERGENT-FREE
AQUEOUS ENVIRONMENT.
Olga B. Popova
, Guizhen Fan,
Mariah R. Baker, Joanita Jakana, Wah Chiu, Steven J. Ludtke,
Irina I. Serysheva
575-P
os
B
oard
#B330
LIGAND-INDUCED CONFORMATIONAL CHANGES IN TETRA-
MERIC IP3R1 REVEALED BY SINGLE-PARTICLE CRYO-EM.
Guizhen Fan
, Olga B. Popova, Steven J. Ludtke, Irina I. Serysheva
576-P
os
B
oard
#B331
COUPLED GATING OF RYANODINE RECEPTORS: EVIDENCE
FOR A ROLE OF PHYSICAL RYR-RYR INTERACTIONS.
Paula L. Diaz-Sylvester
, Jake T. Neumann, Sidney Fleischer,
Julio A. Copello
577-P
os
B
oard
#B332
PHOSPHORYLATION OF MAUROCALCINE STRONGLY
MODIFIES ITS EFFECT ON TYPE 1 RYANODINE
RECEPTOR.
Wei Feng
, Michel Ronjat, Yao Dong, Eloi Bahembera,
Michel De Waard, Isaac N. Pessah
578-P
os
B
oard
#B333
EFFECTS OF AMINO-TERMINAL DISEASE-ASSOCIATED
MUTATIONS ON THE CICR ACTIVITY OF RYR1 CHANNEL.
Takashi Murayama
, Nagomi Kurebayashi, Toshiko Yamazawa,
Hideto Oyamada, Shigeru Takemori, Katsuji Oguchi, Takashi Sakurai
579-P
os
B
oard
#B334
FUNCTIONAL ANALYSIS OF RYANODINE RECEPTOR
CARRYING MALIGNANT HYPERTHERMIA ASSOCIATED
MUTATIONS.
Toshiko Yamazawa
, Takashi Murayama,
Hideto Oyamada, Junji Suzuki, kazunori Kanemaru,
Nagomi Kurebayashi, Shigeru Takemori, Masamitsu Iino
580-P
os
B
oard
#B335
MALIGNANT HYPERTHERMIA ASSOCIATED MUTATIONS IN
S2-S3 LOOP OF TYPE 1 RYANODINE RECEPTOR CALCIUM
CHANNEL ALTER CALCIUM DEPENDENT INACTIVATION.
Angela C. Gomez, Timothy Holford,
Naohiro Yamaguchi
581-P
os
B
oard
#B336
RYANODINE RECEPTOR INTERACTION WITH FKBP12 IS
MODULATED BY THE RYR N-TERMINUS REPEAT REGION.
Polly Marino,
F. Anthony Lai
, Lynda Blayney
582-P
os
B
oard
#B337
MODULATION OF RYANODINE RECEPTORS AND THE CA
2+
ATPASE OF SARCOPLASMIC RETICULUM BY ANTIEPILEPTIC
AGENTS.
Yuanzhao Lv
, Paula L. Diaz-Sylvester, Julio A. Copello
583-P
os
B
oard
#B338
C. ELEGANS AS A MODEL TO STUDY RYANODINE RECEPTOR
FUNCTION IN AGING.
Alisa Umanskaya
, Daniel Andersson,
Wenjun Xie, Steven Reiken, Andrew Robert Marks
Calcium Signaling I (Boards #B339–#B363)
584-P
os
B
oard
#B339
PHOSPHODIESTERASE EXPRESSION PATTERN AND ACTIV-
ITY PARTITIONING IN LIPID RAFT AND IN NON-LIPID-RAFT
MICROENVIRONMENT IN CARDIAC SINOATRIAL NODAL
CELLS. Antoine Younes,
Yevgeniya Lukyanenko
, Alexey Lyashkov,
Kirill Tarasov, Syevda Sirenko, Bruce Ziman, Magdalena Juhaszova,
David R. Graham, Edward G. Lakatta
585-P
os
B
oard
#B340
CA
2+
CYCLING PROTEINS PHOSPHORYLATION IN ISOLATED
SINOATRIAL NODAL CELLS MODULATES THE
STOCHASTICITY OF SPONTANEOUS DIASTOLIC LOCAL CA
2+
RELEASES WHICH REGULATE THE ACTION POTENTIAL
CYCLE LENGTH AND ITS BEAT-TO-BEAT VARIATION.
Dongmei Yang
, Alexey E. Lyashkov, Bruce D. Ziman, Edward G. Lakatta
586-P
os
B
oard
#B341
COUPLED-CLOCK PACEMAKER SYSTEM BECOMES
DYSFUNCTIONAL WITH AGING. Syevda Sirenko, Magdalena
Juhaszova, Jie Liu, Ismayil Ahmet,
Steven J. Sollott
, Edward G. Lakatta
587-P
os
B
oard
#B342
CONTRIBUTION OF CA-REGULATED ION CURRENTS TO
THE ACTION POTENTIAL MORPHOLOGY DURING CARDIAC
ALTERNANS.
Giedrius Kanaporis
, Lothar A. Blatter
