46
Biophysical Society 58
th
Annual Meeting, San Francisco, California
Voltage-gated K Channels I
(Boards #B457–#B486)
702-P
os
B
oard
#B457
HIGH YIELD EXPRESSION OF THE HUMAN
ETHER-à-GO-GO
RELATED GENE (HERG) IN
SACCHAROMYCES CEREVISIAE
.
Karen Molbaek
, Peter Scharff-Poulsen, Dan A. Klaerke,
Per Amstrup Pedersen
703-P
os
B
oard
#B458
education
travel
awardee
EXPRESSION AND PURIFICATION OF A FUNCTIONAL
HERG PORE DOMAIN FOR BIOPHYSICAL AND
ELECTROPHYSIOLOGICAL STUDIES.
Maïwenn Beaugrand
,
Sumit Kalsi, Andrée E Gravel, Christopher D. Johnson, Neville Wright,
Jason C Young, Maurits R. R. de Planque, Isabelle Marcotte,
Philip T. F. Williamson
704-P
os
B
oard
#B459
EAG DOMAINS REGULATE LQT MUTANT HERG CHANNELS
IN INDUCED PLURIPOTENT STEM CELL-DERIVED
CARDIOMYOCYTES.
Qiangni Liu
, Matthew C. Trudeau
705-P
os
B
oard
#B460
THE ROLE OF THE CYCLIC NUCLEOTIDE BINDING HOMOLOGY
DOMAIN IN VOLTAGE AND CALCIUMDEPENDENT GATING OF
EAG POTASSIUMCHANNELS.
Eva Loerinczi
, Avril Newman,
Sophie Draycott, Frederick W. Muskett, John S. Mitcheson
706-P
os
B
oard
#B461
INSIGHTS INTO MOLECULAR BASIS OF HERG INHIBITION
BY STUDYING A LIBRARY OF DOFETILIDE DERIVATIVES.
Priyanka Saxena
, Tobias Linder, Anna Stary-Weinzinger,
Adriaan P IJzerman, Eugen Timin, Gerhard Franz Ecker, Steffen Hering
707-P
os
B
oard
#B462
SENSITIVITY OF FLECAINIDE INHIBITION OF HERG
CHANNELS TO CHANNEL INACTIVATION.
Dario Melgari
,
Aziza El Harchi, Cristopher E. Dempsey, Jules C. Hancox
708-P
os
B
oard
#B463
HIGH AFFINITY BLOCK OF HERG1 CHANNELS IS WEAKLY
DEPENDENT ON INACTIVATION.
Wei Wu
709-P
os
B
oard
#B464
cpow
travel
awardee
INVERSTIGATING STEREOSELECTIVITY OF PHARMACOLOGICAL
INHIBITION OF HERG CHANNELS.
Yi H. Zhang
, Aziza EI Harchi,
Christopher E. Dempsey, Jules C. Hancox
710-P
os
B
oard
#B465
REGULATION OF HERG C-TERMINAL ISOFORM EXPRESSION
BY MODIFIED U1 SMALL NUCLEAR RNA.
Qiuming Gong
,
Matthew R. Stump, Zhengfeng Zhou
711-P
os
B
oard
#B466
HERG CHANNEL VOLTAGE SENSOR MOVEMENT PRECEDES
PORE OPENING.
Samuel J. Goodchild
, David Fedida
712-P
os
B
oard
#B467
INTERACTIONS OF EXTRACELLULAR DIVALENT IONS AND
HYDROGEN WITH THE OUTER PORE OF THE CARDIAC
POTASSIUM CHANNEL HERG. Chris Yoon, Scott Loeb,
Peter Nilsson,
Alan Miller
713-P
os
B
oard
#B468
A SALT BRIDGE LINKS CNBHD CONFORMATION TO THE
GATING MACHINERY IN EAG POTASSIUM CHANNELS.
Yaxian Zhao
, Phu Tran, Joao Morais Cabral, Gail A. Robertson
714-P
os
B
oard
#B469
IN KCNQ1 CHANNELS, A LONG QT MUTATION INDUCES A
REGULATION BY CHOLESTEROL INSTEAD OF PHOSPHATI-
DYLINOSITOL-4,5-BISPHOSPHATE.
Fabien C. Coyan
,
Mohamed-Yassine Amarouch, Fayal Abderemane Ali, Julien Piron,
Jérome Mordel, Céline S. Nicolas, Marja Steenman, Jean Mérot,
Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró,
Gildas Loussouarn
715-P
os
B
oard
#B470
A PAIR OF PHENYLALANINE RESIDUES ON THE S4 AND S5
SEGMENTS CREATE A PHYSICAL AND ENERGY BARRIER FOR
THE VOLTAGE SENSOR IN KCNQ1/KCNE1 CHANNEL.
Koichi Nakajo
, Yoshihiro Kubo
716-P
os
B
oard
#B471
ENDOPLASMIC RETICULUM SAC1 4-PHOSPHATASE REDUCES
PLASMA MEMBRANE KCNQ2/3 CURRENTS.
Eamonn J. Dickson
,
Jill B. Jensen, Bertil Hille
717-P
os
B
oard
#B472
KCNQ1 EXPRESSION MODULATES HERG CURRENT BY
REMOVING INACTIVATION.
Carlos G. Vanoye
, Richard C. Welch,
Alfred L. George
718-P
os
B
oard
#B473
INTERACTION BETWEEN KCNQ1 GAIN-OF-FUNCTION
RESIDUES.
Carlos G. Vanoye
, Richard C. Welch, Brett M. Kroncke,
Alfred L. George, Charles R. Sanders
719-P
os
B
oard
#B474
MODULATION OF K
V
2.1 AND K
V
2.1/K
V
6.4 CHANNELS BY
AUXILIARY KCNE SUBUNITS.
Elke Bocksteins
, James S. Trimmer,
Dirk J. Snyders
720-P
os
B
oard
#B475
A NOVEL COMPOUND TARGETING KV7.2/3 CHANNELS
RELIEVES INFLAMMATORY AND NEUROPATHIC PAIN.
Asher S. Peretz
, Eti Patrich, Polina Kornilov, Nataly Menaker,
Bernard Attali
721-P
os
B
oard
#B476
I
KS
ACTIVATORS SHIFT THEIR BINDING SITES IN
THE KCNQ1 CHANNEL AFTER KCNE1 ASSOCIATION - IN
SILICO PREDICTIONS AND EXPERIMENTAL TESTS.
Yu Xu
,
Yuhong Wang, Mei Zhang, Min Jiang, Gea-Ny Tseng
722-P
os
B
oard
#B477
CALCIUM-INDEPENDENT POTENTATION OF KV7.2 CURRENT
DENSITY BY CALMODULIN.
Carolina Gomis-Perez
,
Virginia Soldovieri, Araitz Alberdi, Paolo Ambrosino, Alessandro Alaimo,
Ganeko Bernardo-Seisdedos, Pilar Areso, Maurizio Taglialatela,
Alvaro Villarroel
723-P
os
B
oard
#B478
KV7.2/7.3 CHANNELS ARE ENHANCED DURING STRIATAL
DEVELOPMENT AND PROMOTE NEURONAL FUNCTIONAL
MATURATION OF IPS CELL-DERIVED NEURONS.
Vsevolod Telezhkin
, Belinda A.N. Thompson, Monica Pardo,
Gerardo Garcia-Diaz Barriga, David A. Brown, Josep M. Canals, Nicholas
D. Allen, Paul J. Kemp
724-P
os
B
oard
#B479
TAMOXIFEN INHIBITION OF KV7.2/KV7.3 CHANNELS.
Tania Ferrer
, Iván Arael Aréchiga Figueroa, Mark S. Shapiro,
Martin Tristani-Firouzi, José A. Sánchez-Chapula
