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An IV or SC continuous infusion is initiated at a rate determined
by the total dose and duration of effect of bolus doses
.
For example,
if sufficient pain relief for 15 min with 5 mg of ketamine,
è
infusion of 20 mg/h would be appropriate.
In patients receiving large-dose opioids,
it is often possible (& desirable) to immediately reduce the opioid by 25%–50%
In practice
è
ketamine , administered in
subanesthetic
doses
Typical effects of
anesthetic
doses of ketamine do not pose
problems
(e.g., salivation, sedation, loss of airway reflexes, and
hallucinations)
More & better treatment…?