1027 / 1578
/
/
Multi-center analysis:
King et al Radiat Oncol 2013
Risk-group Follow-up
Low
36 mo
Intermediate 31 mo
High
23 mo
1100 patients
8 institutions
All patients enrolled in phase II studies
Matthias Guckenberger - ESTRO SBRT Course 2017
9
Ø
No difference between 5 x 7Gy to 5 x 8Gy
07.09.17
/
/
PSA nadir vs SBRT dose
Matthias Guckenberger - ESTRO SBRT Course 2017
10
Ø
Lower PSA nadir worth the increased
toxicity?
07.09.17
Sunnybrook experience: 3 prospective trials
• 35 Gy / 5 fractions / 29 days
• 40 Gy / 5 fractions / 29 days
• 40 Gy / 5 fractions / 11 or 29 days
SBRT dose
Median PSA @ 3a GU toxicity grade 2+
35 Gy
0.64 ng/ml
5%
40 Gy
0.27 ng/ml
48%
Helou Radiother Oncol 2017