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Matthias Guckenberger - ESTRO SBRT Course 2017
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Series
Median
Follow-Up
Robotic SABR
King
2.7 years
Katz
72 months
Chen
28 months
Friedland
24 months
Oliai
Low-dose
27 months
High-dose
37 months
Meier
30 months
Gantry-Based SABR
Kim
24.5 months as per dose
group
Menkarios
33 months
Loblaw
55 months
Mantz
Minimum 5 years
Published data about SBRT for Prostate cancer
Phase I/II
No .of.
Patients
Risk Category
Median Follow Up
King 2013
1100 All risk groups
36 months
Katz 2014
477
Low/Intermediate
72 months
Chen 2013
100
All risk groups
2.3 years
Freidland 2009
112
Low/Intermediate
24 months
Oliai 2012
70
All risk groups
27 months for low dose
37 months for high dose
Meier 2015
309
Low/Intermediate
3 years
Loblaw 2013
84
Low
55 months
Menkarios 2012
80
Low risk
33 months
Mantz 2014
102
Low
Minimum 5 years
Kim 2014
91
Low/Intermediate
42 months
Late toxicity
Biochemical control
Ø
Few, early studies with small patient numbers and
intermediate follow-up
/
/
Toxicity
Ø
Late toxicity = preliminary
Ø
Relevant GU toxicity
0
5
10
15
20
25
30
35
40
45
50
Acute GI
Late GI
Acute GU Late GU
Proportion of patients (%)
McBride et a. 2012
Madsen et al. 2007
Boike et al. 2011
King et al. 2012
Katz et al. 2011
Jabbari et al. 2012
Matthias Guckenberger - ESTRO SBRT Course 2017
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07.09.17