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Matthias Guckenberger - ESTRO SBRT Course 2017
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• Prostate Cancer: Multi-focal and poly-clonal disease
• HOWEVER: mono-clonal origin of metastatic spreat
• Clinically significant cancer
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GS ≤ 6 w/o G pattern 4 or 5
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Organ-confined disease
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Tumour volume <0.5 cm
3
Liu Nat Med 2009
Ahmend NEJM 2009
Metastatic spreat of prostate cancer
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Matthias Guckenberger - ESTRO SBRT Course 2017
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Ø
MP MRI valuable tool for detection of clinically significant cancer
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Accuracy insufficient for focal therapy only
Donati Radiology 2013
Multiparametric MRI for detection of
clinically significant cancer
Rais-Bahramia Urology 2013