1266 / 1578
/
Proton re-irradiation
Ø
Overall, results appear similar to Photon re-irradiation
Chao JTO 2017
Multi-Institutional Prospective Study of Reirradiation with Protons:
Ø
Median interval 19 months; median CTV 108cc
Ø
Conventionally fractionated 66Gy, 2/3 concomitant CT
11.5% grade V toxicity
Median OS 15 months
07.09.17
ESTRO SBRT 2017 - Matthias Guckenberger
35
/
Proton re-irradiation
Ø
Limitation of overall volume and central overlap volume
Chao JTO 2017
07.09.17
ESTRO SBRT 2017 - Matthias Guckenberger
36
Factors influencing toxicity
At the initiation of the study, patients
were stratified as either low volume
(CTV <250 cm3) or high volume (
CTV
>250 cm3
).
The high-volume patients in the full
thoracic cohort
of
the proton
reirradiation
protocol
were
subsequently
deemed infeasible
because of inability to complete the
prescribed treatment course owing
to toxicity
.