1265 / 1578
/
„High-dose“ re-irradiation
Ø
Selected patients: long interval and median target
size <100cc in all studies basis for full dose Re-RT
Drodge Ann Palliat Med 2014
Study
Patients
(#)
Interval
(months)
Re-irradiation
(Gy)
Cumulative
(Gy)
Wu 2003
23
13
51
NS
Okamoto 2002
34
23
50
110
Kruser 2013
48
19
56
NS
Tada 2005
14
16
50
NS
Ebara 2007
44
13
40
102
Griffioena 2014
24
51
60
120
07.09.17
ESTRO SBRT 2017 - Matthias Guckenberger
33
/
„High-dose“ re-irradiation
Ø
Relevant but manageable toxicity
Ø
Reasonable OS
Drodge Ann Palliat Med 2014
Study
Toxicity G V
Median OS
Wu 2003
0
14
Okamoto 2002
0
15
Kruser 2013
0
13
Tada 2005
0
7
Ebara 2007
0
7
Griffioena 2014
N=3
14
07.09.17
ESTRO SBRT 2017 - Matthias Guckenberger
34