1260 / 1578
/
Dose and fractionation
Damast IJROBP 2010
Significantly improved LC
after
5 x 6Gy
Compared to
5 x 4Gy
Ø
Use of fractionated protocols
Ø
30Gy in 5 Fx, but still 25% recurrences within 12 months
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/
Spine SBRT as re-treatment
Evidence-based clinical practice:
• 1
st
RT course with ~30Gy and ~12 months interval
• Fractionated re-irradiation:
• 30Gy in 5 fractions
• 3 / 5 studies did not assume spinal cord recovery
Study
# patients /
cases
Dose 1st RT course
(median)
Interval (median
months)
Reirradiation TD /
fraction (median)
Accumulated
dose (median)
Milker-Zabel 2003
18 / 19
38Gy
18
39.6Gy / 22
NS
Mahan 2005
8 / 8
30Gy
NS
30Gy / 15
48Gy
Sahgal 2009
25 / 37
36Gy
11
24Gy / 3
NS
Choi 2010
42 / 51
40Gy
19
20Gy / 2
76Gy
Sterzing 2010
36 / 36
30Gy
18
30Gy / 10
45Gy
Damast 2010
94 / 97
30Gy
NS
20-30Gy / 5
54.3Gy
Garg 2011
59 / 63
30Gy
NS
27-30Gy / 3-5
NS
Mahadevan 2011
60 / 81
30Gy
20
24-30Gy / 3-5
NS
Chang 2012
49 / 54
39.2Gy
25
27Gy / 3
83.4Gy
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