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Dose effect relationship in NSCLC
•
High irradiation doses required for local tumor control
•
Effect on OS limited due to competing risk of systemic
progression
Perez Cancer 1987
Martel Lung Cancer 1999
40Gy
50Gy
60Gy
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
5
/
Dose effect relationship in SBRT for NSCLC
Ø
Dose effect relationship in SBRT
Ø
Local tumor control and OS
Ø
LQ model for adjustment of variable dose per fraction
All patients
Medically operable patients
Onishi Cancer 2004
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
6