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LQ model versus “extended” biological
models
Ø
LQ model sufficient for description of clinical data
Linear quadratic model
Linear quadratic linear model
Universal Survival Curve
Pade Linear Quadratic
SBRT - stage I NSCLC SRS & SRT - brain mets
Shuryak Radiother Oncol 2015
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
11
/
LQ model versus “extended” biological
models
Ø
Significant fit of all models
Ø
Alpha / Beta ratio of 20Gy, > 10Gy
Klement Radiother Oncol 2017
Ø
Best fit of regrowth model
Linear quadratic model
Linear quadratic linear model
Universal Survival Curve
Modified Linear quadratic model
Modified Linear quadratic linear model
Regrowth model
Liu Radiother Oncol 2017
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
12