226 / 1578
/
Variability in treatment doses
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
Year
0
20
40
60
80
100
120
140
160
Prescribed PTV encompassing dose (BED)
Average
Average +/- 1 standard deviation
95% confidence interval
Ø
Huge variability in irradiation doses
Ø
Learning curve with escalation of prescription dose
Guckenberger JTO 2013
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
9
/
Applicability of LQ model in SBRT:
TCP of local tumor control
LQ model
LQ-L model
Ø
Clear dose effect relationship in fractionated SBRT
Ø
LQL-model
not
statistically superior to LQ model
Guckenberger Radiother Oncol 2013
07.09.17
Matthias Guckenberger - ESTRO SBRT Course 2017
10