144-145 / 427
Analytical Challenges:
N b f
i l
h i PDE5 i hibi
•
um er o potent a synt et c
n tors:
–
more than 100 known analogs
h 50 l
d d l
–
more t an ana ogs reporte as a u terants
•
Availability of reference standards
i
f d l
•
Invent veness o a u terators:
–
exotic analogs
mixtures of analogs
–
–
embedding of adulterants into capsule walls
•
Complex and variable dietary supplement matrices