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Thin Layer Chromatography (TLC)
d l
d f
l
d
•
Screening an pre iminary i enti ication imite to
known analogs with reference standards
•
Cheap, fast but not very sensitive
•
HPTLC can improve sensitivity (densitometric
analysis of spots can be used for quantitation)
Examples:
‐
Cai et al., J. Liquid Chromatogr. Relat. Technol. 33 (2010) 1287–1306
(8 compounds)
‐
Abourashed et al., J. Planar Chromatogr. Mod. TLC 18 (2005) 372–376
(sildenafil)
‐
Reddy et al., J. Planar Chromatogr. Mod. TLC 19 (2006) 427–431
(sildenafil)