Working Group Chair Presentation Book

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Bioassay Based on PDE5 Inhibition
• Screening based on the common mode of action of
PDE5 inhibitors
• Bioassays developed for screening of suitable drug
candidates to detect their inhibition activity
Examples:
‐ PDE GloTM (Promega) ‐ homogenous bioluminescent cAMP‐
PDE/cGMP‐PDE assay
‐ PDE5A Assay Kit (BPS Bioscience) – fluorescence‐based
GMP PDE5A c ‐ assay