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Nuclear Magnetic Resonance (NMR)
f l f
l
d
•
Power u or structure e uci ation
•
Technological advances (new NMR experiments
and data processing tools) improved sensitivity and
enabled measurements in solutions
•
Diffusion ordered spectroscopy (DOSY) NMR
b d d ff
ff
ll
–
separation ase on i usion coe icients, a owing
fingerprinting of active ingredients and excipients
•
Potential for screening, identification, and
quantitation of adulterants
Examples:
l
l
h
d l
(
)
‐ Ba ayssac et a ., J. P arm. Biome . Ana . 50 2009 602–612.
‐ Silva et al., Magn. Reson. Chem. 51 (2013) 169‐176