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Non‐Targeted MS Analysis
•
Analyte‐specific conditions not used for data acquisition
•
Full‐scan MS analysis (precursor ion and/or all‐ion
fragmentation)
•
Increased selectivity using AM/HR MS(‐MS)
•
Data‐dependent experiments with ion trap or hybrid
i t
t (Q T Q TOF Q E ti ) b d k
ns rumen s ‐ rap, ‐ , ‐ xac ve ase on nown or
predicted structures or common (characteristic) MS
fragments
•
Screening of known and unknown adulterants
Examples:
‐
H.M. Lee & B.J. Lee, Food Addit. Contam. 28 (2011) 396–407
‐
Shi et al., J. Chromatogr. A (doi: 10.1016/j.chroma.2013.12.030)