744 / 1266
OS n=21 pts
PFS n=21 pts
1.00
0
0.00
0.20
0.40
0.60
0.80
1 2 3
4 5
6 7 8
Years
21 13 12 10 10 9
5
3 2
21 10 8 7
6 6
2
1 1
At risk
can be spared from radiation therapy with a good outcome
In children < 3 years:
French study BB-SFOP
(Dufour
et al
., Eur J Oncol 2006)
Single arm phase II study of
radiation-sparing
approach
in young children with newly
diagnosed HGG
neurosurgery + carboplatin/procarbazine,
cisplatin/etoposide and vincristine/
cyclophosphamide over a 16-month period
XRT only in case of recurrence or progression
Medium age
= 23 months
5-year OS
= 59%
5-year PFS
= 35%
Median f/u
= 5.2 years
Last f/u:
12/12 children alive (10 without XRT)