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The most appropriate candidates for ASCR are those with complete or
near-complete resection before myeloablative therapy
Chemotherapy and autologous stem cell rescue
But…
Marachelian A et al. Bone Marrow Transplant 200
• At the expense of significant morbidity and mortality as a
consequence of the regimens themselves.
• The associated side effects and resultant poor quality of life
have led many investigators to question the benefit of high-
dose chemotherapy with ASCR despite the potential for
better disease control.
The use of high-dose chemotherapy with ASCR may contribute to long-
term disease control