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Women for Cancer Research
GOOD WILL
Newsletter 15 January 2016
New Scripps Florida Compound
Successfully Targets
Hard-to-Treat Breast Cancer
Some good news about breast cancer from Scripps Florida. Findings from a new
study suggest a potent new therapeutic approach for a number of hard-to-treat
breast enzyme called casein kinase 1δ (CK1δ) has emerged as a highly
vulnerable therapeutic target. Increased expression of the enzyme is common
to breast cancer, including the difficult-to-treat subtype called “triple negative
breast cancer,” which affects 10 to 20 percent of breast cancer patients.
“The best news is that we have been able to treat CK1δ-expressing breast cancers with a highly selective and
potent inhibitor developed by Bill Roush’s lab that triggers rapid tumor cell death,” said Derek Duckett, an
associate professor on the Scripps Florida campus.
The new compound, calledSR-3029, was remarkably successful at blocking the growth of tumors in both animal
models and in studies with tumor tissue from breast cancer patients.
“These results are just the tip of the iceberg,” said Roush, who is professor, associate dean and executive
director of medicinal chemistry at Scripps Florida. “Inhibitors such as SR-3029 are being studied in a host of
different cancers, and we are hopeful this platform can be translated into clinical applications.”
The Frenchman's Creek Women for Cancer Research (WFCR) has raised over $1 million for Scripps Florida in
support of the research being done in the Cancer Biology Department. WFCR has an ongoing partnership
withThe Scripps Research Institute in the challenge of conquering women’s cancer through research....and this
year’s schedule of events will help Scripps Florida get even closer to this goal.
“Please join us for the first event of the new year on January 7th for “Cocktails and Conversation” at the Scripps
Research Institute hosted by the Women for Cancer Research (WFCR). Come meet world-class scientists and
hear more about the amazing discoveries happening at Scripps Florida. For more information, please contact
Stephanie Langlais at 561-228-2551 or
There are many exciting events benefitting Scripps Research planned again this season.
1. Cocktail Reception and Auction on January 7 th at Scripps Florida.
2. Home Tours on January 24th at Frenchman’s Creek.
3. Tennis and Pickleball Tournament on January 25th.
4. Golf Tournament and Luncheon on January 26th.
To learn more aboutWFCR and/or any of these events, please contact the Food and Beverage Office
at 561-868-6370.