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823 patients with stage II/III rectal

cancer

Randomly assigned

Preoperative 28 x 1.8 Gy + 5FU

Postoperative 31 x 1.8 Gy + 5FU

(

5 FU: 120 h CI, 1000 mg/m

2/day

, week 1 & 5)

Introduction

2

Sauer et al, N Eng J Med 2004