Flipping Book - IMRT

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Adverse effects of long-course chemoRT
 Radiation enteritis = primary acute/late side effect
 German trial: preop chemoRT less toxic than postop(1)
 Acute grade ≥ 3 toxicity rate up to 5 times higher with the
addition of 5-FU to preoperative RT as compared to
preoperative RT alone(2)
 Intensified chemotherapy + RT:
5
(1)Sauer et al., N Engl
J Med 2004
(2)Gérard et al., J Clin
Oncol 2006