47 / 1544
UZ Brussel approach
Alternative strategy UZ Brussel: IG-IMRT + simultaneous integrated
boost (SIB) by helical tomotherapy
To decrease the toxicity
by reducing the irradiated volumes of small bowel and bladder
by IG-IMRT
by omitting concomitant 5-FU chemotherapy
To maintain the oncological safety
by delivery of a simultaneous integrated boost to bad T3 (CRM
≤
2mm) and T4 tumors
Phase II Study: primary endpoint 2-year local control
≤
3/100 patients with local failure
10
De Ridder and Engels et al, Int J Radiat Oncol Biol Phys and Radiother Oncol 2008 - 2014