49 / 1544
Dose-volume constraints for IMRT:
small bowel
Baglan et al. (n=40, 3D-CRT)
V15 < 150cc: no grade 3+ acute GI toxicity
V15 > 150cc: 50% grade 3+ acute GI toxicity
Gunnlaugsson et al. (n=28, 3D-CRT)
V15
≤
150cc: 11% diarrhea
V15 > 150cc: 52% diarrhea
Tho et al. (n=41, 3D-CRT)
V5-V30 correlated with severity of diarrhea
Yang et al. (n=177, IMRT/3D-CRT)
V45 < 3%: no grade 2+ diarrhea
V45
≥
27%: 20% grade 2+ diarrhea
Reis et al. (n=45, 3D-CRT)
V5 < 292cc: 29% grade 2-3 diarrhea
V5 > 292cc: 82% grade 2-3 diarrhea
QUANTEC (Marks LB et al.): V15 < 120cc (< 10% risk of
severe acute GI toxicity)
12