50 / 1544
Dose-volume constraints for IMRT:
bladder
Less radiosensitive as compared to small bowel
e.g. primary RT gynaecological/urological malignancies (often doses > 70Gy)
Sauer et al: only 2% grade 3+ late GU toxicity
Appelt et al. (n=345, preoperative long-course chemoRT):
first report on dose-volume relationship for acute urinary toxicity in
rectal cancer
No clinically significant benefit is to be expected from
IMRT with regard to GU toxicity
13