Techniques to Reduce SAMe Product Degradation
Challenge: SAMe’s Extreme Instability
1) Chemical Method
Binding SAMe molecule with some compounds
e.g. Trehalose, Toluenesulfonic Acid
Binding sites: -COOH, -NH2, S
Techniques to Reduce SAMe Product Degradation
Challenge: SAMe’s Extreme Instability
2) Physical Method
Tablets - Enteric Coating
Temperature - Refrigeration, Freezing
Oxygen Trap
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Shelf Life -
Two years for current SAMe tablets
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However, does not stop Racemization