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Which Model Should BioWatch Adopt?
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FDA: Food and Drug Administration
ARGOS: dAtabase for Regulatory Grade micrObial Sequences
FDA ARGOS
Curated database of microbial
reference-grade genomes for
regulatory use
• Common clinical agents and
near neighbors
• Supporting the development
of medical countermeasures
• US-initiated
Livermore Metagenomic
Analysis Toolkit (LMAT)
Comprehensive searchable database
for strain level typing
• 116 billion bases of genomic data;
~5X more bacterial and viral
genomic data than other databases
• Microbial background
characterization
Quality Standards for Sequencing
Ladner et al. Mbio. 2014
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