105 / 266
78
M
O
N
D
A
Y
1317-Pos
Board B294
DAMPENED ACTIVITY OF SINGLE RYANODINE RECEPTOR CHANNELS IN
MICE DEVOID OF TRIC-A.
Katja Witschas
, Fiona O’Brien, Elisa Venturi,
Sam El-Ajouz, Matthew Beech, David Eberhardt, Tsunaki Iida, Miyuki
Nishi, Hiroshi Takeshima, Rebecca Sitsapesan
1318-Pos
Board B295
SIMVASTATIN ACTIVATES SINGLE SKELETAL RYR1 CHANNELS BUT EXERTS
MORE COMPLEX REGULATION OF THE CARDIAC ISOFORM, RYR2.
Elisa
Venturi
, Katja Witschas, Sabine J. Lotteau, Emma Steer, Derek S. Steele,
Sarah C. Calaghan, Rebecca Sitsapesan
1319-Pos
Board B296
CPOW TRAVEL AWARDEE
SIMVASTATIN HAS PROFOUND EFFECTS ON SARCOPLASMIC RETICULUM
CA
2+
LEAK IN SKELETAL BUT NOT CARDIAC MUSCLE: A MECHANISM FOR
MYOPATHY.
Sabine Lotteau
, Zhaokang Yang, Elisa Venturi, Emma Steer,
Katja Witschas, Rebecca Sitsapesan, Derek Steele, Sarah Calaghan
1320-Pos
Board B297
AXIAL MEMBRANE TUBULES IN ATRIAL CARDIOMYOCYTES CONFINE UL-
TRARAPID INTRACELLULAR CALCIUM SIGNALS THROUGH A NEW SUPER-
HUB MECHANISM. Sören Brandenburg, Tobias Kohl, George S.B. Williams,
Konstantin Gusev, Eva Wagner, Elke Hebisch, Christopher W. Ward, W. J.
Lederer,
Stephan E. Lehnart
1321-Pos
Board B298
CARDIAC PACEMAKER CELL FUNCTION AT A SUPER-RESOLUTION SCALE
OF SIM: DISTRIBUTION OF RYRS, CALCIUM DYNAMICS, AND NUMERI-
CAL MODELING.
Victor A. Maltsev
, Alexander V. Maltsev, Magdalena
Juhaszova, Syevda Sirenko, Oliver Monfredi, Hari Shroff, Andrew York,
Steven J. Sollott, Edward G. Lakatta, Michael D. Stern
1322-Pos
Board B299
RELATIVE CONTRIBUTION OF LOCAL CA
2+
RELEASES (LCRS) AND AP-IN-
DUCED CA
2+
TRANSIENT DECAY TO DIASTOLIC DEPOLARIZATION IN RAB-
BIT SA NODE CELLS.
Oliver J. Monfredi
, Alexander Maltsev, Sean Parsons,
Bruce Ziman, Edward Lakatta, Michael D. Stern, Victor A. Maltsev
1323-Pos
Board B300
ENHANCED RYR2 CHANNEL ACTIVITY BUT REDUCED CA
2+
SPARK OC-
CURRENCE IN FAILING MICE CARDIOMYOCYTES.
Linwei Li
, Gema Ruiz-
Hurtado, Maria Fernandez-Velasco, Angelica Rueda, Florence Lefebvre,
Yue Yi Wang, Philippe Mateo, Cecile Cassan, Barnabas Gellen, Jean Pierre
Benitah, Ana M. Gomez
1324-Pos
Board B301
CHARACTERIZATION OF CA
2+
-INDUCED CA
2+
RELEASE VIA RYR2 CARRYING
ARRHYTHMOGENIC MUTATIONS.
Nagomi Kurebayashi
, Takashi
Murayama, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino, Takashi
Sakurai
1325-Pos
Board B302
INHIBITION OF RYR2 ACTIVITY BY INTRACELLULAR FLECAINIDE EFFECTIVE-
LY SUPPRESSES ARRHYTHMOGENIC CA WAVES IN INTACT VENTRICULAR
MYOCYTES FROM CASQ2 -/- MICE.
Dmytro Kryshtal
, Björn C. Knollmann
1326-Pos
Board B303
MANIPULATION OF RYANODINE RECEPTOR ACTIVITY MODULATES AUTO-
IMMUNE RESPONSES IN MICE. Natalia C. Osipchuk, Paul D. Allen, Lillian
Cruz-Orengo, Athena Soulika,
Alla Fomina
1327-Pos
Board B304
HIGH-THROUGHPUT SCREENS TO DISCOVER INHIBITORS OF LEAKY RY-
ANODINE RECEPTOR CALCIUM CHANNELS. Robyn T. Rebbeck, Florentin R.
Nitu, David D. Thomas, Donald M. Bers,
Razvan L. Cornea
1328-Pos
Board B305
FLUORESCENCE-LABELED IMPERACALCIN BINDS TO OPEN RYR2 CHAN-
NELS IN MOUSE VENTRICULAR MYOCYTES.
Liang Xiao
, Yi Yang, Geogina
B. Gurrola, Florentin R. Nitu, José Luis Puglisi, Liming Zhang, Razvan L.
Cornea, Donald M. Bers, Héctor H. Valdivia
1329-Pos
Board B306
STRUCTURAL DYNAMICS OF CALMODULIN IN REGULATION OF CARDIAC
CALCIUM RELEASE IN HEALTH AND DISEASE.
Megan R. McCarthy
, Robyn
T. Rebbeck, Razvan L. Cornea, David D. Thomas
1330-Pos
Board B307
CARDIAC RYANODINE RECEPTOR CHANNEL GATING IS MODIFIED DURING
BLOCKER-INDUCED CHANGES IN ION PERMEATION.
Saptarshi
Mukherjee
, Nia L. Thomas, Alan J. Williams
1331-Pos
Board B308
FRET-BASED MAPPING OF CALMODULIN WITHIN THE RYANODINE RECEP-
TOR.
Robyn T. Rebbeck
, Bengt Svensson, Florentin R. Nitu, Montserrat
Samso, Donald M. Bers, David D. Thomas, Razvan L. Cornea
1332-Pos
Board B309
CALMODULIN REGULATION OF RYANODINE RECEPTORS (RYR2) DIFFERS
IN FAILING AND NON-FALING HUMAN HEARTS DUE TO DIFFERENCES IN
RYR2 PHOSPHORYLATION.
Derek R. Laver
, Kafa Walweel, Ye Win Oo, Dirk
van Helden, Cris dos Remedios, Peter Molenaar
1333-Pos
Board B310
PROTEIN PHOSPHATASE-1 INCREASES CALCIUM SPARK FREQUENCY IN
MURINE CARDIOMYOCYTES VIA MODULATION OF RYR2 PHOSPHORYLA-
TION.
Duilio Michele Potenza
, Miguel Fernandez-Tenorio, Ernst Niggli
1334-Pos
Board B311
ABLATION OF TWO MAJOR PHOSPHORYLATION SITES IN RYR2 ALTER
SARCOPLAMIC RETICULUM CALCIUM HANDLING AND INCREASES THE
PROPENSITY TO ATRIAL FIBRILLATION.
Roberto Ramos Mondragon
, Em-
manuel M. Camors, Yangyang Bao, Cicero B. Willis, Carmen Valdivia, Lori
Isom, Jose Jalife, Hector H. Valdivia
1335-Pos
Board B312
NITROSYLATION OF RYR2 PREVENTS ACTIVATION OF CA WAVES INDUCED
BY REDOX-MEDIATED INTERSUBUNIT CROSS-LINKING. Elisa Bovo, Stefan
R. Mazurek, Jody L. Martin, Pieter P. de Tombe,
Aleksey V. Zima
1336-Pos
Board B313
ZINC MODULATES SKELETAL RYANODINE RECEPTOR FUNCTION RESULT-
ING IN ALTERED SARCOPLASMIC RETICULUM CALCIUM RELEASE.
Gavin B.
Robertson
, Benedict Reilly-O’Donnell, Craig Balmforth, Samantha J. Pitt
Cardiac Smooth and Skeletal Muscle
Electrophysiology I (Boards B314 - B335)
1337-Pos
Board B314
ELECTROPHYSIOLOGICAL PROPERTIES OF HUMAN INDUCED PLURIPO-
TENT STEM CELL-DERIVED CARDIOMYOCYTES CULTURED ON A FLEXIBLE
MATRIGEL SUBSTRATE.
Lili Wang
, Tromondae K. Feaster, Dmytro O.
Kryshtal, Charles C. Hong, Bjorn C. Knollmann
1338-Pos
Board B315
VARIABILITY OF THE FIELD POTENTIAL DURATION OF STEM CELL-DERIVED
CARDIOMYOCYTES IS A PROARRHYTHMIC INDICATOR.
Andrew Bruening-
Wright
, Carlos A. Obejero-Paz, James Kramer, Arthur M. Brown
1339-Pos
Board B316
IMPEDANCE AND COMBINED EXTRACELLULAR FIELD POTENTIAL
RECORDINGS OF CIPA REFERENCE COMPOUNDS ON IPS CARDIOMYO-
CYTES.
Corina Bot
, Sonja Stoelzle-Feix, Nadine Becker, Krisztina Juhasz,
Ulrich Thomas, Leo Doerr, Rodolfo Haedo, Matthias Beckler, Joerg Oest-
reich, Michael George, Andrea Brüggemann, Niels Fertig
1340-Pos
Board B317
EDUCATION TRAVEL AWARDEE
MODELING ELECTROPHYSIOLOGICAL INTERACTIONS BETWEEN MES-
ENCHYMAL STEM CELLS AND CARDIOMYOCYTES FOR IMPROVED CELL
DELIVERY CARDIOTHERAPEUTICS.
Joshua Mayourian
, Ruben M. Savizky,
Eric A. Sobie, Kevin D. Costa