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M
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D
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83
1446-Pos
Board B423
MATURATION TOWARDS PURE β-MYOSIN PROTEIN EXPRESSION AND
CORRESPONDING FUNCTIONAL PROPERTIES OF INDIVIDUAL HESC-
CARDIOMYOCYTES.
Natalie Weber
, Meike Wendland, Stephan Greten,
Kristin Schwanke, Bogdan Iorga, Martin Fischer, Cornelia Geers-Knörr, Jan
Hegermann, Christoph Wrede, Ulrich Martin, Bernhard Brenner, Robert
Zweigerdt, Theresia Kraft
1447-Pos
Board B424
A TUNED TENSION REGULATES THE CONTRACTILITY OF CARDIOMYO-
CYTES DIFFERENTIATED FROM INDUCED PLURIPOTENT STEM CELLS.
Alexandre J. Ribeiro
, Yen-Sin Ang, Robin E. Wilson, Renee N. Rivas,
Deepak Srivastava, Beth L. Pruitt
1448-Pos
Board B425
CONTRACTILE FUNCTION OF PERMEABILIZED HUMAN EMBRYONIC STEM
CELL-DERIVED CARDIOMYOCYTES WITH DEFINED MYOSIN PROTEIN
ISOFORM EXPRESSION. Bogdan Iorga, Meike Wendland, Natalie Weber,
Stephan Greten, Kristin Schwanke, Ulrich Martin, Robert Zweigerdt,
Theresia Kraft,
Bernhard Brenner
1449-Pos
Board B426
CROSS-BRIDGE KINETICS IN RAT PAPILLARY MUSCLE FIBERS THAT CARRY
α-MHC AND β-MHC BY SINUSOIDAL ANALYSIS. Tarek S. Karam, John J.
Michael, Chandra Murali,
Masataka Kawai
1450-Pos
Board B427
CROSSBRIDGE RECRUITMENT DYNAMICS ARE DIVERGENTLY AFFECTED
BY α/β-MYOSIN HEAVY CHAIN ISOFORMS IN CARDIAC MUSCLE FIBERS
CONTAINING THE HYPERTROPHIC CARDIOMYOPATHY MUTATION (A30V)
AND PROTEIN KINASE C PHOSPHOMIMETIC (T203E) IN MOUSE CARDIAC
TROPONIN T.
Alexis Mickelson
, Sampath Gollapudi, Murali Chandra
1451-Pos
Board B428
INTERPLAY BETWEEN THE EFFECTS OF DILATED CARDIOMYOPATHY MU-
TATION (R206L) AND THE PROTEIN KINASE C PHOSPHOMIMIC (T204E)
OF RAT CARDIAC TROPONIN T ARE DIFFERENTLY MODULATED BY α- AND
β-MYOSIN HEAVY CHAIN ISOFORMS.
John J. Michael
, Murali Chandra
1452-Pos
Board B429
THE EFFECT OF PEDIATRIC SPECIFIC HYPERTROPHIC CARDIOMYOPATHY
MUTATIONS ON THE BIOMECHANICS OF BETA CARDIAC MYOSIN.
Arjun S.
Adhikari
, Kristina Bezold Kooiker, Shirley Sutton, Daniel Bernstein, Leslie
A. Leinwand, Kathleen M. Ruppel, James A. Spudich
1453-Pos
Board B430
ADP-STIMULATED CONTRACTION: A PREDICTOR OF THIN-FILAMENT
ACTIVATION IN CARDIAC DISEASE.
Vasco Sequeira
, Aref Najafi, Paul J.
M. Wijnker, Cris dos Remedios, Michelle Michels, Diederik W.D. Kuster,
Jolanda van der Velden
1454-Pos
Board B431
CARDIAC FIBROSIS ALTERS CALCIUM SENSITIVITY AND MYOFILAMENT RE-
LAXATION.
Farid Moussavi-Harami
, Maria V. Razumova, Stephen Farris,
Galina V. Flint, Soley Olafsson, Sonette Steczina, Yuanhua Cheng Cheng,
Alice W. Racca, April Stempien-Otero, Michael Regnier
1455-Pos
Board B432
PRELOAD-INDUCED CHANGES IN SYSTOLIC AND DIASTOLIC PERFOR-
MANCE IN THE YOUNG AND AGED MURINE HEART.
Adam B. Veteto
,
Kerry S. McDonald, Timothy L. Domeier
1456-Pos
Board B433
CID TRAVEL AWARDEE
MYOCARDIUM FROM THE LEFT AND RIGHT VENTRICLES OF HUMAN
HEARTS HAVE SIMILAR MECHANICAL PROPERTIES.
Cheavar A. Blair
,
Maya E. Guglin, Arnold Stromberg, Kenneth S. Campbell
1457-Pos
Board B434
EDUCATION TRAVEL AWARDEE
CONTRACTILE DIFFERENCES IN LEFT AND RIGHT VENTRICLES OF HEALTHY
HUMAN HEARTS.
Divya Duggal
, Janhavi Nagwekar, Sangram Raut, Ryan
Rich, Hriday Das, Zygmunt Gryczynski, Ignacy Gryczynski, Julian Borejdo
1458-Pos
Board B435
STRUCTURAL AND BIOCHEMICAL KINETICS OF CARDIAC MYOSIN AND ITS
PERTURBATION BY A KNOWN HEART FAILURE DRUG INVESTIGATED WITH
TRANSIENT TIME-RESOLVED FRET.
John A. Rohde
, David D. Thomas,
Joseph M. Muretta
1459-Pos
Board B436
OMECAMTIV MECARBIL ENHANCES ACTIN AFFINITY AND SLOWS FORCE
PRODUCTION IN HUMAN β-CARDIAC MYOSIN. Anja M. Swenson, Cheavar
Blair, Christopher Fetrow, William C. Unrath, Wanjian Tian, Maya Guglin
Guglin, Kenneth S. Campbell,
Christopher M. Yengo
1460-Pos
Board B437
EFFECT OF RLC N-TERMINAL TAILS ON THE STRUCTURE AND DYNAMICS
OF CARDIAC MYOSIN.
Arianna Fornili
, Elena Rostkova, Franca Fraternali,
Mark Pfuhl
1461-Pos
Board B438
CARDIOMYOPATHY MUTATION IN VENTRICULAR ESSENTIAL LIGHT CHAIN
OF CARDIAC MYOSIN ALTERS STRUCTURAL AND FUNCTIONAL INTERAC-
TION WITH ACTIN.
Piyali Guhathakurta
, Ewa Prochniewicz, David D.
Thomas
1462-Pos
Board B439
EFFECTS OF MYOSIN LIGHT CHAIN PHOSPHORYLATION ON LENGTH-DE-
PENDENT MYOSIN KINETICS IN RAT CARDIAC VENTRICLES.
Bertrand CW
Tanner
, Hannah C. Pulcastro, Peter O. Awinda, Jason J. Breithaupt
1463-Pos
Board B440
EFFECTS OF IVS6-1 MUTATION IN MYL2 ASSOCIATED WITH CARDIOSKEL-
ETAL MYOPATHY AND EARLY CARDIAC DEATH OF INFANTS.
Zhiqun Zhou
,
Wenrui Huang, Jingsheng liang, Danuta Szczesna-Cordary
1464-Pos
Board B441
RARE CARDIOMYOPATHY PHENOTYPES ASSOCIATED WITH MUTATIONS
IN MYOSIN LIGHT CHAINS.
Chen-Ching Yuan
, Jingsheng Liang, Katarzyna
Kazmierczak, Zhiqun Zhou, Rosemeire Kanashiro-Takeuch, Joshua M.
Hare, Thomas C. Irving, Danuta Szczesna-Cordary
1465-Pos
Board B442
UPREGULATING COMPLIANT TITIN IN THE HEART ATTENUATES LEFT VEN-
TRICULAR STIFFNESS IN A MOUSE MODEL WITH DIASTOLIC DYSFUNC-
TION.
Mei Methawasin
, Joshua G. Strom, Vanessa Fernandez, Chandra
Saripalli, John E. Smith III, Henk L. Granzier
1466-Pos
Board B443
EXERCISE MITIGATES INCREASED DIASTOLIC STIFFNESS IN THE TITIN IA
KO MOUSE.
Rebecca E. Slater
, Mei Methawasin, Josh Strom, Chandra
Saripalli, Henk L. Granzier
1467-Pos
Board B444
A NOVEL ROLE FOR PP5 IN REGULATING TITIN PHOSPHORYLATION AND
FUNCTION IN THE HEART. Judith Krysiak, Andreas Unger, Nazha Hamdani,
Peter Boknik,
Wolfgang A. Linke
Skeletal Muscle Mechanics, Structure, and
Regulation (Boards B445 - B469)
1468-Pos
Board B445
COMPLIANCE ACCELERATES RELAXATION IN STRIATED MUSCLE BY
ALLOWING MYOSIN HEADS TO MOVE RELATIVE TO ACTIN.
Kenneth S.
Campbell
1469-Pos
Board B446
MYOSIN BINDING TO ACTIN IN THE 3D SARCOMERE LATTICE.
Srboljub M.
Mijailovich
, Boban Stojanovic, Djordje Nedic, Michael A. Geeves