130 / 266
T
U
E
S
D
A
Y
103
Symposium
Optogenetics in Neuroscience
4:00 pm - 6:00 pm, Petree Hall C
Chair
Edward S. Boyden, MIT
1796-Symp
4:00 pm
TOOLS FOR ANALYZING AND REPAIRING COMPLEX BIOLOGICAL SYSTEMS.
Edward Boyden
1797-Symp
4:30 pm
CONTROLLING BIOLOGICAL PATHWAYS WITH PHOTOPHARMACOLOGY.
Dirk Trauner
1798-Symp
5:00 pm
TOOLS FOR ANATOMICAL AND FUNCTIONAL ANALYSIS OF WIDELY DIS-
TRIBUTED BRAIN NETWORKS.
Viviana Gradinaru
1799-Symp
5:30 pm
NATURAL ANION CHANNEL RHODOPSINS: A NEW FAMILY OF TOOLS FOR
OPTOGENETIC NEURAL INHIBITION.
John L. Spudich
Symposium
p-ATPases: Structure, Mechanism, and Disease
4:00 pm - 6:00 pm, Petree Hall D
Chair
David Gadsby, Rockefeller University
1800-Symp
4:00 pm
HYBRID FUNCTION OF THE NA/K-ATPASE: PROTON IMPORT ACCOMPA-
NYING NA/K EXCHANGE.
David Gadsby
, Natascia Vedovato
1801-Symp
4:30 pm
SNAPSHOTS OF P-TYPE ATPASES - FROM CRYSTAL STRUCTURES TO
SINGLE-MOLECULE STUDIES.
Poul Nissen
1802-Symp
5:00 pm
THE NEW KIDS IN THE BLOCK: FE
2+
TRANSPORT P-ATPASES.
José M.
Argüello
1803-Symp
5:30 pm
SECRETORY PATHWAY CALCIUM ATPASES IN BREAST CANCER.
Rajini Rao
,
Donna Dang, José P. Llongueras
Platform
Cardiac Muscle Mechanics and Structure
4:00 pm - 6:00 pm, Room 502A
Co-Chairs
Clara Franzini-Armstrong, University of Pennsylvania
Howard Young, University of Alberta, Canada
1804-Plat
4:00 pm
FUNCTIONAL IMBALANCE AMONG INDIVIDUAL CARDIOMYOCYTES
CAUSED BY CELL-TO-CELL VARIATION IN MUTANT MRNA EXPRESSION.
A POSSIBLE TRIGGER FOR HYPERTROPHIC CARDIOMYOPATHY. Theresia
Kraft, Mirza Makul, Julia Beck, Judith Montag, Ante Radocaj, Andreas
Perrot, Antonio Francino, Francesc Navarro-Lopéz, Cristobal G. dos
Remedios,
Bernhard Brenner
1805-Plat
4:15 pm
DIFFERENTIAL EFFECTS OF CAMKII ACTIVITY IN HCM-LINKED TNT MUTA-
TIONS.
Sarah J. Lehman
, Lauren Tal-Grinspan, Melissa Lynn, Mark E.
Anderson, Jil C. Tardiff
1806-Plat
4:30 pm
UNDERSTANDING VISCOELASTICITY CHANGES IN SINGLE CELLS USING
VARIABLE INDENTATION-RATE VISCOELASTIC ANALYSIS.
Matthew A.
Caporizzo
, Patrick Robison, Alexey Bogush, Benjamin L. Prosser, David M.
Eckmann, Russell J. Composto
1807-Plat
4:45 pm
CELLULAR STRESS AFFECTS THE NUCLEOSKELETON IN DILATED CARDIO-
MYOPATHY. Marlene Pluess, Thomas Iskratsch, Pauline Bennett, Joseph
Dwyer, Pragati Pandey, Cristobal dos Remedios,
Elisabeth Ehler
1808-Plat
5:00 pm
SIMULTANEOUS HIGH-PRECISION IMAGING OF LOCAL CALCIUM AND
SINGLE SARCOMERE LENGTH IN RAT NEONATAL CARDIOMYOCYTES
VIA EXPRESSION OF YELLOW CAMELEON-NANO140 IN Z-DISCS. Seiichi
Tsukamoto,
Kotaro Oyama
, Teruyuki Fujii, Fuyu Kobirumaki-Shimozawa,
Togo Shimozawa, Seine A. Shintani, Shin’ichi Ishiwata, Norio Fukuda
1809-Plat
5:15 pm
ELECTRON TOMOGRAPHY OF MITOCHONDRIAL NANOTUNNELS IN A
CPVT MODEL WITH RYR2 LOSS-OF-FUNCTION MUTATION.
Manuela
Lavorato
, V.Ramesh Iyer, Yang-Ting Zhao, Hector Valdivia, Clara Franzini-
Armstrong
1810-Plat
5:30 pm
CORRELATING STRUCTURE AND FUNCTION IN HUMAN GENETIC VARI-
ANTS OF PHOSPHOLAMBAN AND SARCOLIPIN. Joseph O. Primeau,
Gareth P. Armanious, Jessica L. Gifford, Catharine A. Trieber,
Howard S.
Young
1811-Plat
5:45 pm
THE N-TERMINI OF SARCOLIPIN AND PHOSPHOLAMBAN PLAY AN IM-
PORTANT ROLE IN DISTINCT REGULATION OF SARCO-ENDOPLASMIC RE-
TICULUM CA
2+
ATPASE (SERCA) FUNCTION.
Sanjayaka K. Sahoo
, Sana A.
Shaikh, Danesh H. Sopariwala, Naresh C. Bal, Dennis S. Bruhn, Wojciech
Kopec, Himanshu Khandelia, Muthu Periasamy
Platform
Protein Stability, Folding, and Chaperones II
4:00 pm - 6:00 pm, Room 502B
Co-Chairs
Logan Ahlstrom, University of Michigan
Patrick Wintrode, University of Maryland
1812-Plat
4:00 pm
OVERCOMING HETEROGENEITY TO STUDY THE STRUCTURE AND AS-
SEMBLY OF SMALL HEAT-SHOCK PROTEIN CHAPERONES WITH NON-
AGGREGATING CLIENTS.
Miranda Collier
, Justin Benesch
1813-Plat
4:15 pm
INTERNATIONAL TRAVEL AWARDEE
STRUCTURE AND STABILITY OF HSP60 AND GROEL IN SOLUTION.
Caterina Ricci
, Giampaolo Barone, Donatella Bulone, Giosalba Burgio,
Rita Carrotta, Fabio Librizzi, Antonella Marino Gammazza, Maria Rosalia
Mangione, Antonio Palumbo Piccionello, Pier Luigi San Biagio, Angelo
Spinello, Francesco Spinozzi, Silvia Vilasi, Maria Grazia Ortore
1814-Plat
4:30 pm
QUANTIFICATION OF MACROMOLECULAR CROWDING IN LIVING CELLS.
Arnold Boersma
, Boqun Liu, Christoffer Aberg, Bert Poolman
1815-Plat
4:45 pm
INSIGHTS FROM THE FIRST PRINCIPLES BASED LARGE SCALE PROTEIN
THERMOSTABILITY CALCULATIONS.
Vytautas Gapsys
, Servaas
Michielssens, Daniel Seeliger, Bert L. de Groot
1816-Plat
5:00 pm
HIGHLY CHARGED PROTEINS ARE THE ACHILLES’ HEEL OF AGING PRO-
TEOMES.
AdamM. R. de Graff
, Michael J. Hazoglou, Ken A. Dill