144 / 266
T
U
E
S
D
A
Y
117
2129-Pos
Board B273
SINGLE VESICLE RECORDING IN HIPPOCAMPAL ‘XENAPSES’ REVEALS
DIFFUSIONAL DISPERSION OF SV PROTEINS AFTER FUSION.
Julia Trahe
,
Ulrike Keller, Yaroslav Tsytsyura, Carsten Reissner, Jacob Piehler, Markus
Missler, Jurgen Klingauf
2130-Pos
Board B274
FUSION BETWEEN V-SNARE NANODISCS AND “FLIPPED” T-SNARE CELLS:
CONTROL OF FUSION PORE NUCLEATION AND LIFETIMES BY SNARE PRO-
TEIN TRANSMEMBRANE DOMAINS. Zhenyong Wu, Sarah Marie Auclair,
Oscar Daniel Bello, Wensi Vennekate, Natasha Dudzinski, Shyam Sundar
Krishnakumar,
Erdem Karatekin
2131-Pos
Board B275
PHYSIOLOGICAL IMPLICATIONS OF SLOW FUSION PORE EXPANSION ON
PROTEIN DISCHARGE: LIKELY INHIBITION OF TISSUE PLASMINOGEN AC-
TIVATOR BY ITS CO-PACKAGED PROTEIN INHIBITOR.
Kevin P. Bohannon
,
Mary A. Bittner, Daniel Axelrod, Ronald W. Holz
2132-Pos
Board B276
MUNC18-1-REGULATED STAGE-WISE SNARE ASSEMBLY UNDERLYING
SYNAPTIC EXOCYTOSIS.
Yongli Zhang
2133-Pos
Board B277
EFFECT OF TWO DISEASE-CAUSING MUTATIONS ON THE ENERGETICS
AND KINETICS OF SNARE ASSEMBLY.
Aleksander A. Rebane
, Shyam
Krishnakumar, James E. Rothman, Yongli Zhang
2134-Pos
Board B278
ROLES OF VAMP7 IN DROSOPHILA SYNAPTIC TRANSMISSION.
Ismael D.
Santiago
, Bryan Meléndez, J. Troy Littleton, Ramon Jorquera
2135-Pos
Board B279
SYNAPSIN NULL INCREASES CALCIUM SENSITIVITY OF VESICLE FU-
SION AND ALTER SHORT-TERM SYNAPTIC MEMORY AT DROSOPHILA
NMJ.
Agustin Gonzalez Ruiz
, Ramon A. Jorquera
2136-Pos
Board B280
MATHEMATICAL MODELING SUPPORTS THE HYPOTHESIS THAT SYNAP-
TOTAGMIN RINGS CLAMP FUSION.
Jie Zhu
, Ben O’Shaughnessy, James
Rothman
2137-Pos
Board B281
MOLECULAR DYNAMICS SIMULATIONS OF SYNAPTOTAGMIN BINDING TO
LIPID BILAYERS.
Maria Bykhovskaia
2138-Pos
Board B282
SYNAPTOTAGMIN-1 BINDS TO PIP2-CONTAINING MEMBRANE BUT NOT
TO SNARES AT PHYSIOLOGICAL IONIC STRENGTH.
Yongsoo Park
2139-Pos
Board B283
INVERSION OF LIGAND BINDING PREFERENCES IN RE-ENGINEERED DYS-
FERLIN C2AV1.
Faraz Harsini
, Anne Rice, Kerry Fuson, R. Bryan Sutton
2140-Pos
Board B284
MULTIVALENT MEMBRANE LIPID TARGETING BY THE CALCIUM-INDEPEN-
DENT C2 DOMAINS OF GRANUPHILIN: EVIDENCE FROM COMPUTATION
AND EXPERIMENT. Abena Watson-Siriboe, Jack Henderson, J. Ryan
Osterberg, Daniel T. Giardina, Marissa DeLima, Hai Lin,
Jefferson Knight
2141-Pos
Board B285
IS BURSTING MORE EFFECTIVE THAN SPIKING IN EVOKING PITUITARY
HORMONE SECRETION? A SPATIOTEMPORAL SIMULATION STUDY OF
CALCIUM DIFFUSION AND EXOCYTOSIS.
Alessia Tagliavini
, Joel Tabak,
Richard Bertram, Morten G. Pedersen
Intracellular Calcium Channels and Calcium
Sparks and Waves II (Boards B286 - B304)
2142-Pos
Board B286
SHG-2PF IMAGING OF LOCAL CA
2+
AND SUB-SARCOMERE CONTRACTION
IN LIVE CARDIOMYOCYTES. Samir Awasti,
Leighton T. Izu
, Ziliang Mao,
Zhong Jian, Ye Chen-Izu, James W. Chan
2143-Pos
Board B287
ONE AND TWO-PHOTON CALCIUM UNCAGING WITH VISIBLE LIGHT IN
CARDIAC MYOCYTES.
Radoslav Janicek
, Hitesh K. Agarwal, Graham C.R.
Ellis-Davies, Ernst Niggli
2144-Pos
Board B288
MOLECULAR ASSEMBLY OF THE MITOCHONDRIAL CALCIUM UNIPORTER
COMPLEX.
Ming-Feng Tsai
, Christopher Miller
2145-Pos
Board B289
MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING PRO-
MOTES CALCIUM ALTERNANS AND WAVES IN VENTRICULAR MYO-
CYTES.
Zhen Song
, Richard Gordan, James N. Weiss, Lai-Hua Xie, Zhilin Qu
2146-Pos
Board B290
MITOCHONDRIAL SK CHANNELS ATTENUATE CA-DEPENDENT ARRHYTH-
MIA IN HYPERTROPHIC HEARTS BY REGULATING MITO-ROS-DEPENDENT
OXIDATION AND ACTIVITY OF RYR. TaeYun Kim, Weiyan Li, Radmila
Terentyeva, Karim Roder, Man Liu, Ian Greener, Richard T. Clements,
Samuel C. Dudley, Gideon Koren, Bum-Rak Choi,
Dmitry Terentyev
2147-Pos
Board B291
DIASTOLIC CALCIUM LEAK AND THE ROLE OF ZINC.
Benedict Reilly-
O’Donnell
, Gavin B. Robertson, Angela Karumbi, Alan J. Stewart,
Samantha J. Pitt
2148-Pos
Board B292
ASSOCIATION BETWEEN β3-ADRENOCEPTOR ACTIVATION AND INTRA-
CELLULAR FREE ZINC ION INCREASE CONTRIBUTES TO HYPERGLYCEMIA-
INDUCED CARDIAC ER-STRESS. Erkan Tuncay, Aysegul Toy,
Belma Turan
2149-Pos
Board B293
SHEAR STRESS ENHANCES CA
2+
SPARK OCCURRENCE IN RAT VENTRICU-
LAR MYOCYTES VIA MITOCHONDRIAL NADPH OXIDASE-REACTIVE OXY-
GEN SPECIES SIGNALING.
Jun Wang
, Joon-Chul Kim, Sun-Hee Woo
2150-Pos
Board B294
X-ROS SIGNALING IN ATRIAL MYOCYTES PRODUCES ARRHYTHMOGENIC
CA
2+
WAVES.
Maura Greiser
, Ramzi J. Khairallah, Chris Ward, W. Jonathan
Lederer
2151-Pos
Board B295
NOVEL INSIGHTS INTO SINOATRIAL NODAL CELL LOCAL CALCIUM RELEAS-
ES (LCRS) FROM AUTOMATED COMPUTER ANALYSIS IN SPONTANEOUSLY
BEATING CELLS.
Alexander V. Maltsev
, Sean Parsons, Edward G. Lakatta,
Michael D. Stern, Victor A. Maltsev, Oliver J. Monfredi
2152-Pos
Board B296
SYNCHRONIZATION OF LOCAL CALCIUM RELEASES (LCRS) IN GUINEA
PIG SINGLE, ISOLATED SA NODE CELLS CONTRIBUTES TO GENERATION
OF RHYTHMIC ACTION POTENTIAL-INDUCED CA
2+
TRANSIENTS.
Mary S.
Kim
, Larissa A. Maltseva, Alexander V. Maltsev, Sean P. Parsons, Oliver
Monfredi, Kenta Tsutsui, Syevda Sirenko, Bruce Ziman, Edward G. Lakatta,
Victor A. Maltsev
2153-Pos
Board B297
COMPUTATIONAL ANALYSIS OF HEART-FAILURE-RELATED REMODEL-
ING OF CYTOSOLIC AND NUCLEAR CALCIUM HANDLING IN THE CANINE
ATRIAL CARDIOMYOCYTE.
Jordi Heijman
, Xiao Yan Qi, Dobromir Dobrev,
Stanley Nattel