148 / 266
T
U
E
S
D
A
Y
121
2227-Pos
Board B371
ISOPIMARIC ACID - A PROMISCUOUS ION CHANNEL MODULATOR AND
A POTENTIAL DRUG CANDIDATE AGAINST ATRIAL FIBRILLATION. Sajjad
Salari,
Malin Silverå Ejneby
, Johan Brask, Fredrik Elinder
2228-Pos
Board B372
TOWARDS A STRUCTURAL UNDERSTANDING OF CANTú DISEASE ASSOCI-
ATED GATING PERTURBATIONS IN THE KATP POTASSIUM CHANNEL.
Eva-Maria Plessl
, Anna Stary-Weinzinger
2229-Pos
Board B373
MATHEMATICAL MODELING OF HUMAN PANCREATIC ALPHA-CELLS:
INSIGHT INTO THE ROLE OF SGLT2 IN GLUCAGON SECRETION.
Morten G.
Pedersen
, Ingela Ahlstedt, Eva-Marie Andersson, Sven Göpel
2230-Pos
Board B374
CFTR POTENTIATORS EXERT DIFFERENT EFFECTS ON HUMAN, MURINE,
AND XENOPUS CFTR.
Guiying Cui
, Netaly Khazanov, Brandon B. Stauffer,
Daniel T. Infield, Barry R. Imhoff, Hanoch Senderowitz, Nael A. McCarty
2231-Pos
Board B375
CFTR ON AN AUTOMATED PATCH CLAMP SYSTEM. Rasmus B. Jacobsen,
Naja Møller M. Sørensen
2232-Pos
Board B376
SLC6A14 ENHANCES CFTR CHANNEL ACTIVITY IN THE CYSTIC FIBROSIS
AFFECTED LUNG EPITHELIUM.
Saumel Ahmadi
, Sunny Xia, Michelle Di
Paola, Wan Ip, Johanna Rommens, Tanja Gonska, Christine E. Bear
2233-Pos
Board B377
IDENTIFICATION OF CARDIAC MITOCHONDRIAL CHLORIDE INTRACEL-
LULAR CHANNEL (CLIC) PROTEINS AND THEIR PHYSIOLOGICAL FUNC-
TION.
Devasena Ponnalagu
, Shubha Gururaja Rao, Piotr Bednarczyk,
Yansheng Feng, Jason Farber, Rushi Thanawala, Ahmed Tafsirul Hussain,
Jean Chrisostome Bopassa, Adam Szewczyk, Harpreet Singh
Ligand-gated Channels II
(Boards B378 - B398)
2234-Pos
Board B378
CHARACTERIZATION OF THE INTERACTION OF THE INTRACELLULAR DO-
MAIN OF 5-HT
3A
RECEPTORS WITH THE CHAPERONE PROTEIN RIC-3.
Elham Pirayesh
, Frankie Leung, Akash Pandhare, Michaela Jansen
2235-Pos
Board B379
PENTAMERIC STRUCTURE OF THE SOLUBLE INTRACELLULAR DOMAIN
OF 5-HT
3A
RECEPTORS.
Akash Pandhare
, Petar N. Grozdanov, Michaela
Jansen
2236-Pos
Board B380
MASS SPECTROMETRY COUPLED WITH CROSSLINKING AS A STRUCTURAL
TOOL FOR STRUCTURAL DETERMINATION OF HUMAN α1 GLYCINE RECEP-
TOR.
Rathna J. Veeramachaneni
, Chelsee Donelan, Michael Cascio
2237-Pos
Board B381
PRINCIPAL COMPONENTS FROM LIGAND-GATED ION CHANNEL STRUC-
TURES ENABLE ENSEMBLE STUDIES OF MICROSECOND-SCALE TRANSI-
TIONS.
Ozge Yoluk
, Laura Orellana, Edward J. Bertaccini, James R. Trudell,
Erik Lindahl
2238-Pos
Board B382
CATION-π INTERACTIONS: COMPUTATIONAL ANALYSES OF THE AROMAT-
IC BOX MOTIF AND THE FLUORINATION STRATEGY FOR EXPERIMENTAL
EVALUATION OF CYS-LOOP RECEPTORS AND RELATED STRUCTURES.
Matthew R. Davis
, Dennis A. Dougherty
2239-Pos
Board B383
EXPLORING THE BINDING OF GABA TO THE INSECT RDL RECEPTOR WITH
METADYNAMICS.
Federico Comitani
, Vittorio Limongelli, Carla Molteni
2240-Pos
Board B384
RELATIVE AFFINITIES OF POSITIVE AND NEGATIVE MODULATORS OF
HETEROMERIC GABA(A) RECEPTORS FOR PSEUDO-SYMMETRIC INTER-
SUBUNIT BINDING SITES.
Sruthi Murlidaran
, Reza Salari, Jérôme Hénin,
Grace Brannigan
2241-Pos
Board B385
IDENTIFYING GABA-A RECEPTOR MODULATORS THAT BIND TO INTERSUB-
UNIT SITES IN THE GABA-A RECEPTOR TRANSMEMBRANE DOMAIN.
Selwyn S. Jayakar
, Xiaojuan Zhou, Pavel Y. Savechenkov, Karol S. Bruzik,
Keith W. Miller, Jonathan B. Cohen
2242-Pos
Board B386
INTERACTIONS OF A PHOTOREACTIVE STEROID ANESTHETIC (F4N3-
ALPHAXALONE) WITH HUMAN α1β3γ2 GABA-A RECEPTORS.
David C.
Chiara
, Pavel Y. Savechenkov, Xiaojuan Zhou, Rooma Desai, Alex T. Stern,
Yinghui Zhang, Stuart A. Forman, Karol S. Bruzik, Keith W. Miller, Jonathan
B. Cohen
2243-Pos
Board B387
PULSED ELECTRON PARAMAGNETIC RESONANCE OF SPIN LABELED
HUMAN GABA(A)RS FUNCTIONALLY RECONSTITUTED IN LIPID BILAYERS
SUGGESTS THERE IS SPACE FOR LIPIDS BETWEEN THE SUBUNITS. Yinghui
Zhang, Jessica L. Sarver, Xiaojuan Zhou, David S. Cafiso,
Keith W. Miller
2244-Pos
Board B388
VISIBLE-LIGHT ABSORBING, PHOTOLABILE, QUINONE-BASED PROTECTING
GROUPS FOR ALCOHOLS AND AMINES.
David P. Walton
, Clinton J. Regan,
Oliver S. Shafaat, Chris B. Marotta, Dennis A. Dougherty
2245-Pos
Board B389
A SOLUBLE GABA
A
ρ1 INTRACELLULAR DOMAIN CHIMERA FOR STRUC-
TURAL STUDIES.
Laura J. Delin
, Akash Pandhare, Katharine Jenkins,
Michaela Jansen
2246-Pos
Board B390
ALLOSTERIC GATING PATHWAYS FOR THE PENTAMERIC LIGAND-GATED
ION CHANNEL GLIC. Bogdan Lev, Samuel Murail, Michael Thomas, Marc
Baaden, Marc Delarue,
Toby W. Allen
2247-Pos
Board B391
INSIGHTS INTO GATING MOTIONS OF GLIC VIA PERTURBATION OF CRITI-
CAL PROLINES WITH NON-CANONICAL AMINO ACID PROBES.
Matthew
Rienzo
, Angela R. Rocchi, Stephanie D. Threatt, Dennis A. Dougherty,
Sarah C. R. Lummis
2248-Pos
Board B392
ELUCIDATING PROTON SENSITIVITY AND ACTIVATION IN THE GLOEO-
BACTER VIOLACEUS LIGAND-GATED ION CHANNEL.
Ákos Nemecz
, Zaineb
Fourati, Haidai Hu, Pierre-Jean Corringer, Marc Delarue
2249-Pos
Board B393
A SINGLE MUTATION IN GLIC REVEALS BOTH THE POTENTIATING AND
THE INHIBITORY NATURE OF PROPOFOL.
Stephanie A. Heusser
, Rebecca
J. Howard, Iman Pouya, Göran Klement, Cecilia Borghese, R. Adron Harris,
Erik Lindahl
2250-Pos
Board B394
MOLECULAR INSIGHTS INTO ALLOSTERIC MODULATION OF GLIC GAT-
ING BY MEMBRANE LIPIDS.
Sandip Basak
, Nicolaus Schmandt, Sudha
Chakrapani
2251-Pos
Board B395
RADIAL TILTING OF THE EXTRACELLULAR DOMAIN OF GLIC REVEALED
BY EPR SPECTROSCOPY.
Varun Tiwari
, Abby M. Schuh, Candice S. Klug,
Cynthia Czajkowski