147 / 266
120
T
U
E
S
D
A
Y
2203-Pos
Board B347
ASSESSING THE IN VITRO CARDIOTOXICITY OF SUPERPARAMAGNETIC ION
OXIDE NANOPARTICLES (SPIONS).
Roberta Gualdani
, Andrea Guerrini,
Elvira Fantechi, Claudio Sangregorio, Maria Rosa Moncelli
2204-Pos
Board B348
HERG ION CHANNEL ACTIVITY MEASURED IN PLANAR LIPID BILAYER
ARRAYS: RECONSTITUTION FROM EUKARYOTIC CELL-FREE EXPRESSION
SYSTEM AND CELLULAR MEMBRANE PREPARATIONS.
Ekaterina Zaitseva
,
Juan del Rio Martinez, Srujan Kumar Dondapati, Gerhard Baaken, Sönke
Petersen, Stefan Kubick, Jan C. Behrends
2205-Pos
Board B349
COMPREHENSIVE CARDIAC SAFETY SCREENING: PHARMACOLOGY OF
STEM CELL-DERIVED CARDIOMYOCYTES USING HIGH-THROUGHPUT
AUTOMATED PATCH CLAMP. Nadine Becker,
Claudia S. Haarmann
, Sonja
Stölzle-Feix, Ilka Rinke, Markus Rapedius, Tom Götze, Timo Stengel,
Andrea Brueggemann, Michael George, Niels Fertig
2206-Pos
Board B350
NOVEL LOCAL ANESTHETICS DEMONSTRATE ISOMER-DEPENDENT ANAL-
GESIA IN MICE.
George Kracke
, Monika VanGordon, Kuanysh Kabytaev,
Yulia Sevryugina, Satish Jalisatgi, Fred Hawthorne
2207-Pos
Board B351
USE-DEPENDENT BLOCK OF HUMAN CARDIAC SODIUM CHANNELS BY
GS967.
Franck Potet
, Alfred L. George, Jr
2208-Pos
Board B352
CONFORMATIONAL CHANGES OF THE NMDA RECEPTORS ASSOCIATED
WITH ETHANOL-INDUCED INHIBITION.
Hamid Reza Noori
, Christian
Mücksch, Herbert Urbassek
2209-Pos
Board B353
EXPLORING STRUCTURAL INTERACTIONS OF TARANTULA TOXINS WITH
LIPID MEMBRANES USING ROSETTA AND MOLECULAR DYNAMICS SIMU-
LATION.
Phuong T. Nguyen
, Jon T. Sack, Toby W. Allen, Vladimir
Yarov-Yarovoy
2210-Pos
Board B354
VALIDATION OF KCA3.1 CHANNEL SMALL MOLECULES INTERACTION
SITES PREDICTED BY ROSETTA.
Hai M. Nguyen
, Latika Singh, Heike Wulff,
Vladimir Yarov-Yarovoy
2211-Pos
Board B355
CARDIAC SMALL CONDUCTANCE CALCIUM-ACTIVATED K CHANNELS
MAINTAIN REPOLARIZATION RESERVE IN A PHARMACOLOGICAL MODEL
OF TYPE 3 LONG QT SYNDROME. Jum Suk Ko, Dechun Yin, Thomas H.
Everett, Zhenhui Chen, Michael Rubart,
Peng-Sheng Chen
2212-Pos
Board B356
CALCIUM-ACTIVATED POTASSIUM CHANNELS IN THE MALARIA PARASITE
ERYTHROCYTE CYCLE.
Matthias Garten
, Marika M. Kachman, Svetlana
Glushakova, Joshua Zimmerberg
2213-Pos
Board B357
SUPPRESSION OF KV2-MEDIATED CURRENTS BY THE ANTICONVULSANT
RETIGABINE.
Jeroen I. Stas
, Elke Bocksteins, Dirk J. Snyders
2214-Pos
Board B358
USING VOLTAGE CLAMP FLUOROMETRY TO UNDERSTAND KCNQ CHAN-
NEL PHARMACOLOGY.
Robin Y. Kim
, Stephan A. Pless, Harley T. Kurata
2215-Pos
Board B359
A NEW KCNQ1 MUTATION AT THE S5 SEGMENT THAT IMPAIRS ITS ASSO-
CIATION WITH KCNE1 IS RESPONSIBLE FOR SHORT QT SYNDROME.
Alicia
de la Cruz
, Cristina Moreno, Anna Oliveras, Chiara Bartolucci, Juan R.
Gimeno, Stefano Severi, Antonio Felipe, Teresa Gonzalez, Pier Lambiase,
Carmen Valenzuela
2216-Pos
Board B360
MOLECULAR DYNAMICS SIMULATIONS OF MUTANT K CHANNELS IN-
VOLVED IN SEVERE EARLY ONSET EPILEPSY.
Robert A. Farley
, Yi Shi, Yibo
Wang, Van Ngo, Sergei Noskov
2217-Pos
Board B361
A MISSENSE MUTATION IN THE SELECTIVITY FILTER OF BK AFFECTS THE
CHANNEL’S POTASSIUM CONDUCTANCE.
João L. Carvalho-de-Souza
,
Tomoya Kubota, Xiaofei Du, Ramon Latorre, Christopher M. Gomez,
Francisco Bezanilla
2218-Pos
Board B362
PHARMACOLOGY AND REGULATION OF FUNGAL K2P CHANNELS.
Ryan
W. Manville
, Fernanda S. Povreslo, Andrew Corran, Anthony Lewis
2219-Pos
Board B363
THE 2-PORE DOMAIN POTASSIUM CHANNEL TREK-1 REGULATES CYTO-
KINE SECRETION FROM HUMAN ALVEOLAR EPITHELIAL CELLS INDEPEN-
DENTLY OF POTASSIUM CURRENTS.
Andreas Schwingshackl
, Bin Teng,
Marc Borsotto, Christopher M. Waters
2220-Pos
Board B364
CALCIUM CURRENT PROPERTIES AND LEAK CONDUCTANCE IN MOUSE
MUSCLE FIBERS OVEREXPRESSING A TYPE 1 HYPOKALEMIC PERIODIC
PARALYSIS MUTANT L-TYPE CALCIUM CHANNEL. Clarisse Fuster, Jimmy
Perrot, Christine Berthier, Vincent Jacquemond,
Bruno Allard
2221-Pos
Board B365
MICRODOMAIN-SPECIFIC REMODELLING OF AUTONOMIC REGULATION
OF L-TYPE CALCIUM CHANNELS REVEALED BY SUPER-RESOLUTION SCAN-
NING PATCH CLAMP IN RAT ATRIAL MYOCYTES IN HEART FAILURE.
Alexey
V. Glukhov
, Marina Balycheva, Jose L. Sanchez-Alonso, Navneet Bhogal,
Ivan Diakonov, Marta Mazzola, Giuseppe Faggian, Julia Gorelik
2222-Pos
Board B366
CHARACTERISING THE EFFECTS OF A PEPTIDE DIRECTED AGAINST THE L-
TYPE CA
2+
CHANNEL ON MITOCHONDRIAL FUNCTION IN HYPERTROPHIC
CARDIOMYOPATHY.
Livia C. Hool
, Helena M. Viola, Victoria P.A. John-
stone, Henrietta Cserne Szappanos, Tatiana Tsoutsman, Chris Semsarian,
Christine Seidman
2223-Pos
Board B367
SIMULATION OF L-TYPE CALCIUM CURRENTS USING DIFFERENT EXPERI-
MENTAL DATA SOURCES: FROM CELL LINE TO IPS-DERIVED CARDIOMYO-
CYTE.
Ken Wang
, Gary Mirams, Mark Davies, Antonello Caruso, Denis
Noble, Ruben Alvarez-Sanchez, Antje Christine Walz, Thierry Lave, Franz
Schuler, Thomas Singer, Liudmila Polonchuk
2224-Pos
Board B368
EFFECT OF FLECAINIDE DERIVATIVES ON SARCOPLASMIC RETICULUM
CA
2+
RELEASE CONFIRMS A LACK OF DIRECT ACTION ON THE CARDIAC
RYANODINE RECEPTOR.
Anita Alvarez-Laviada
, Mark L. Bannister, Nia
Lowri Thomas, Sammy A. Mason, Christo L. du Plessis, Abbygail T. Moran,
David Neil-Hall, Hasnah Osman, Mark C. Bagley, Kenneth T. McLeod,
Christopher H. George, Alan J. Williams
2225-Pos
Board B369
FUNDAMENTAL GATING DEFECTS OF SUDDEN CARDIAC DEATH-LINKED
MUTANT CARDIAC RYANODINE RECEPTORS DETERMINE CA
2+
RELEASE
DYNAMICS IN CELLS.
Shanna R. Hamilton
, Chloe Maxwell, Christopher H.
George, Saptarshi Mukherjee, Alan J. Williams, Nia L. Thomas
2226-Pos
Board B370
LOSS OF MYOCARDIAL NNOS MEDIATED BY UPREGULATION OF MIR-31
IN HUMAN ATRIA CONTRIBUTES TO BEGETTING OF ATRIAL FIBRILLA-
TION.
Xing Liu
, Svetlana Reilly, Ricardo Carnicer, Alice Recalde, Anna
Muszkiewicz, Raja Jayaram, Maria Cristina Carena, Matilde Stefanini,
Rohan Wijesurendra, Oliver Lomas, Rana Sayeed, George Krasopoulos,
Alfonso Bueno-Orovio, Blanca Rodriguez, Barbara Casadei