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Effect of uncertainties on observed dose
response relationships
Comparison of model dose response curve (based on published curves, see previous slides), and simulated
„observed“ dose response curves assuming different systematic and random uncertainties.
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
45
65
85
105
125
145
165
Response
Dose (Gy EQD2)
systematic dosimetric uncertainty
e.g. rectum D
2cm³
(+3,+5,+10,+15 % / fx)
random dosimetric uncertainty
e.g. rectum D
2cm³
(
±
10,
±
20,
±
30 % / fx)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
45
65
85
105
125
145
165
Response
Dose (Gy EQD2)
n=10000 patients per dose level, total dose = 45Gy EBRT + 4 fx BT (equal PD for each fx)
model based on
Georg er al. 2012, IJROBP
Nesvacil et al., ESTRO33, 2014
NTCP
TCP