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General

Optimising the values of the

Objective Functions

results to

Optimisation of

the 3D Dose Distribution

.

Due to the fact that in general

Objective Functions

are defined as over-

dosages (High-Objective) or under-dosage(s) (Low-Objective),

Optimisation of

an Objective Function means Minimization of its value (ideally 0) by adjusting

the independent parameter values such as catheter positions, active source

dwell positions and source dwell times

.

Inverse Optimisation and Planning

=

1

=1

Θ −

Objectives & Objective Functions

=

1

=1

Θ −

Under-dosage (low)

Over-dosage (high)