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Tumors showing high
EGFR expression
EGFR overexpression in human tumors
•
NSCLC
40-80%
•
Prostate
40-80%
•
Gastric
33-74%
•
Breast
14-91%
•
Colorectal
25-77%
•
Pancreatic
30-50%
•
Ovarian
35-70%
•
Bladder
31-48%
•
Renal cell
50-90%
•
H&N
80-100%
•
Glioma
40-63%
•
Esophageal 43-89%
High expression generally
associated with
•
Invasion
•
Metastasis
•
Late-stage disease
•
Chemo-/Radiotherapy
resistance
•
Poor outcome