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Cetuximab
(C225)
Trastuzumab
Pertuzumab
No heterodimerization
Stimulation of
endocytosis
Competition to EGF-binding
Inhibition of Dimerization
DIFFERENT BINDING SITES – DIFFERENT MECHANISMS
EXTRACELLULAR DOMAIN OF PROTEIN AS TARGET STRUCTURES!
Multiple downstream mechanisms leading to e.g. radiosensitization