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EGFR as an example
MAPK
MEK
Gene transcription
Cell cycle progression
PI3-K
RAS RAF
SOS
GRB2
PTEN
AKT
STAT
R
K
pY
R
pY
pY
K
proliferation/
maturation
Survival / anti-apoptosis
angiogenesis
metastasi
DNA
myc
Myc
cyclin D1
Cyclin D1
JunFos
P P
hemo-
and
radiotherapy resistance
P-EGFR
-
IR +2Gy
P-EGFR
-
+
EGF