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Activation of signaling cascade
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
P
P
P
P
P
P
P
P
P
P
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
Tyr
extracellular ligand
binding domain
transmembrane
domain
intracellular
tyrosine kinase
domain
activation of signaling cascades
ligand binding
ligand binding
dimerization