859 / 1851
CATNON trial
:
New standard regimen for non-codeleted anaplastic glioma ?
748 patients randomized
12 cycles TMZ improve OS in anaplastic
glioma without 1p/19q codeletion.
MGMT methylation was prognostic for
OS, but did not predict improved
outcome to adjuvant TMZ
Van den Bent MJ. et al. presented at ASCO 2016 annual meeting, Chicago
Overall Survival
RT + adjuvant TMZ
RT alone
p < 0.001
1
2
3
4
5
6
7
8
years
0
0
10
20
30
40
50
60
70
80
90
100