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Major trends and research opportunities in predictive

modelling with relevant contribution from MP: Normal tissues

Incorporation of clinical and

«omics» predictors into

dose-volume

(phenomenological) models:

methods for variable

selection, robustness

assessment, validation

Data-sharing and data-

mining issues

Objective, image-based

scoring of toxicity

(morphological and

functional changes)

Involvement into data

analysis/modelling of clinical

trials/Institutional series

Overcoming organ-based

approach of dose-volume

modelling (considering the 3D

dose distribution,

similarity/dissimilarity

comparisons, multi-structure

models…)

Incorporation of delivered

dose into models (replacing

planned doses)