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Overcoming organ-based approach of
dose-volume modelling
The organ-based DVH approach
is clearly a (useful) “hard
constraint” not reflecting the real
world in many situations:
1) Symptoms may depend on
the dose received by multiple
organs
2) Organs are not “homogenous
entities” from the point of view of
their response to radiation and
their functions
Cella et al. PlosOne2014, Complication Probability Models
for Radiation-Induced Heart Valvular Dysfunction: Do
Heart-Lung Interactions Play a Role?.