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Major trends and research opportunities in predictive
modelling with relevant contribution from MP: Normal tissues
Incorporation of clinical and
«omics» predictors into
dose-volume
(phenomenological) models:
methods for variable
selection, robustness
assessment, validation
Data-sharing and data-
mining issues
Objective, image-based
scoring of toxicity
(morphological and
functional changes)
Involvement into data
analysis/modelling of clinical
trials/Institutional series
Overcoming organ-based
approach of dose-volume
modelling (considering the 3D
dose distribution,
similarity/dissimilarity
comparisons, multi-structure
models…)
Incorporation of delivered
dose into models (replacing
planned doses)