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Overcoming organ-based approach of dose-volume
modelling
Organ-based…an intuitive and natural way to
describe radiotherapy-induced effects
Organs as «independent and homogeneous
entities» is a robust and practically usable
approximation for most end-points
Supported the translation from «qualitative» to
«quantitative» RT ….knowledge condensed
into organ constraints/EUDs/NTCPs
Successful in reducing toxicities by guiding RT
to «safely» deliver treatments respecting
organ-based constraints
Conserving a «flavour» of Radiobiology
(....serial and parallel-like organs…)
«Easy» incorporation in multi-variable
phenomenological models