Particle Therapy 2017

Strength of study design

I. Randomized controlled clinical

trials (RCT)

II. Non-randomized controlled

clinical trials (NRCT)

III. Case series (CS)

IV. Best case series (BCS)

Strength of endpoint

A. Overall survival (OS)

B. Disease-specific survival

(DSS)

C. i. Carefully assessed quality

of life (Qol)

ii. Treatment-induced toxicity

D. Indirect surrogates

i. Disease-free survival

ii. Progression-free survival

iii. Tumor response rate

iv. Local and locoregional

control

Veldeman L. et al. Lancet Oncol. 2008 Apr;9(4):367-